Biologics to Treat Substance Use Disorders Vaccines, Monoclonal Anti
This book is a scientific compendium documenting the state of the art in the discovery and development of vaccines, monoclonal antibodies, and enzymes for the treatment of Substance Use Disorders (SUDs). The book gives detailed consideration to some of th
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Biologics to Treat Substance Use Disorders
Ivan D. Montoya Editor
Biologics to Treat Substance Use Disorders Vaccines, Monoclonal Antibodies, and Enzymes
Editor Ivan D. Montoya National Inst Drug Abuse, Room 4131 National Institutes of Health Bethesda, MD USA
ISBN 978-3-319-23149-5 ISBN 978-3-319-23150-1 DOI 10.1007/978-3-319-23150-1
(eBook)
Library of Congress Control Number: 2015957970 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)
Foreword
The treatment of drug use disorders (DUDs) is challenging because of the clinical nature of these entities and the limited number and efficacy of available pharmacotherapies. Biologics such as vaccines, monoclonal antibodies, and enzymes offer new alternative therapeutic strategies. The aim for these interventions is to prevent the entry of the drug to the brain and thus interfere with its rewarding and neurotoxic effects. This book is the first comprehensive compendium of research in the development of biologics to treat DUDs and drug overdose. Most of the preclinical and clinical work on biologics discussed in this book has been supported by NIDA as part of its commitment to the discovery and development of new treatments. In the development of drug vaccines, a major challenge has been the generation of sufficiently high titers of antibodies to bind to the high concentrations of the drug in the blood of those taking them. As of now, clinical trials with nicotine and cocaine vaccines have been disappointing, but research for the development of vaccines with higher antigenicity is ongoing. Passive immunization with monoclonal antibodies allows the delivery of sufficiently high antibody titers to counteract the drug’s effects and thus offers an intervention with which to treat patie
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