Biomarkers and Machine Learning Applications in Obesity

Next-generation sequencing, multi-omics, high-resolution medical imaging technologies, and a wide range of (smart) sensors have led the biosciences into the big data era. To this end, machine learning approaches are more than ever indispensable to transfo

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ity and Diabetes Scientific Advances and Best Practice Second Edition

Obesity and Diabetes

Joel Faintuch • Salomão Faintuch Editors

Obesity and Diabetes Scientific Advances and Best Practice Second Edition

Editors Joel Faintuch Hospital das Clinicas Sao Paulo University Medical School Sao Paulo, Brazil

Salomão Faintuch Harvard Medical School Beth Israel Deaconess Medical Center Boston, MA, USA

ISBN 978-3-030-53369-4 ISBN 978-3-030-53370-0 https://doi.org/10.1007/978-3-030-53370-0

(eBook)

# Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG. The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland

Foreword

Obesity and diabetes mellitus are two interrelated, chronic, debilitating, incurable diseases that have increased in incidence worldwide. In the USA, over 60% of adult Americans are overweight or obese. Most countries around the world are also seeing dramatically increasing rates of obesity. Although not all people with type 2 diabetes are overweight or obese, the majority are. In addition, while most individuals who suffer from obesity are not diabetic, the incidence of T2DM increases as adiposity increases. So intertwined are these seemingly independent metabolic disorders that some refer to them together as “diabesity.” Despite spending billions of dollars on research and the development of a multitude of different treatments, we have failed to control either disease and find ourselves heading off the cliff. While there has been an explosion of new medications, surgical procedures, and the introduction of metabolic/bariatric devices, the incidence of both diseases continues to rise. It has been estimated that within a few short years, the cost to treat the various related medical conditions of these two