Biomarkers assessment in patients with Chagas disease and systemic arterial hypertension
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PROTOZOOLOGY - ORIGINAL PAPER
Biomarkers assessment in patients with Chagas disease and systemic arterial hypertension Anderson de Oliveira Vieira 1 & Gabriel Antônio Nogueira Nascentes 2 Dalmo Correia 4 & Marlene Cabrine-Santos 5,6
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Ana Carolina de Morais Oliveira 3
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Received: 16 August 2019 / Accepted: 1 November 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Chagas disease (ChD) and systemic arterial hypertension (SAH) are two severe comorbidities that lead to mortality and a reduction in people’s quality of life, with an impact on public health. The aim of this study was to quantify the biomarkers of cardiac injury in patients with ChD and SAH. Eighty patients were divided into four groups: 20 hypertensive patients, 20 ChDhypertensive patients, 20 ChD patients, and 20 normotensive volunteers; all of them came from outpatient’s public health services. Among the evaluated markers for cardiac lesions (creatine kinase, creatine kinase-MB isoform, myoglobin, highsensitive cardiac troponin T[hs-cTnT], B-type natriuretic peptide [BNP], and C-reactive protein), hs-cTnT and BNP were the most appropriate. Importantly, our results showed that the cut off point for hs-cTnT could be < 0.007 ng/mL, which could lead to the early detection of myocardial lesions. The BNP and hs-cTnT levels were high only in the ChD and ChD-hypertensive patient groups, suggesting that Chagas’ disease may play an important role in the increase of these biomarkers. ChD patients, hypertensive or not, with cardiac or cardiodigestive involvement presented significantly higher values of hs-cTnT (p < 0.001) and BNP (p = 0.001) than ChD patients with indeterminate and digestive forms, which strengthens the validation of these markers for the follow-up of clinical cardiac form of ChD. This study suggests that the BNP and hs-cTnT can be used as possible indirect biomarkers of cardiac damage. In addition, the reference values of these biomarkers in Chagas and hypertensive cardiomyopathies should be better understood with further studies. Keywords Trypanosoma cruzi . Chagas’ disease . Hypertension . BNP . hs-cTnT
Introduction Section Editor: Marta Teixeira * Marlene Cabrine-Santos [email protected]; [email protected] 1
Clinical Pathology Service at the Hospital de Clínicas/Ebserh, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais State, Brazil
2
Program of Microbiology and Immunology, Federal Institute of Education, Science and Technology of Triângulo Mineiro, Uberaba, Minas Gerais State, Brazil
3
Biomedicine, Institute of Health Science, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais State, Brazil
4
Infectious Diseases Division, Internal Medicine Department, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais State, Brazil
5
Internal Medicine Department, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais State, Brazil
6
Universidade Federal do Triângulo Mineiro, Av. Getúlio Guaritá, 130, Abadia, Uberaba, Minas Gerais 38025-440, Brazil
Chag
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