Biomechanics of the Gravid Human Uterus
The complexity of human uterine function and regulation is one of the great wonders of nature and represents a daunting challenge to unravel. This book is dedicated to the biomechanical modeling of the gravid human uterus and gives an example of the appli
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Roustem N. Miftahof
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Hong Gil Nam
Biomechanics of the Gravid Human Uterus
Professor Dr. Roustem N. Miftahof Arabian Gulf University College of Medicine and Medical Sciences Department of Physiology 26671 Manama Kingdom of Bahrain [email protected]
Professor Dr. Hong Gil Nam Pohang University of Science and Technology Plant Systems Bio-Dynamics Laboratory San 31, Hyoja Dong, Nam Gu Pohang, Gyungbuk, 790-784 Republic of South Korea [email protected]
ISBN 978-3-642-21472-1 e-ISBN 978-3-642-21473-8 DOI 10.1007/978-3-642-21473-8 Springer Heidelberg Dordrecht London New York Library of Congress Control Number: 2011933468 # Springer-Verlag Berlin Heidelberg 2011 This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: deblik Berlin, Germany Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
Thus, the task is, not to see what no one has yet seen, but to think what nobody has yet thought, about that which everybody sees. E. Schro¨dinger
The complexity of human uterine function and regulation is one of the great wonders of nature and it represents a daunting challenge to unravel. Our current understanding of uterine functions is based mainly on information obtained from in vivo and in vitro experiments as well as subsequently derived concepts presented in a form of “theoretical” models. Most of the research on human myometrium has been aimed at the elucidation of biochemical pathways for contractility. Ethical issues, the lack of standardized methodologies, and a big scatter of experimental data make the performance of such studies and the interpretation of the results difficult. Although experiments are supplying and will continue to offer valuable data at different structural levels on myometrial activity, they fail, however, to provide a holistic view on how the uterus works. Therefore, it is time to bring together previously unconnected pools of knowledge as an integrated system. The use of mathematical ideas, models, and techniques is rapidly growing and is gaining prominence through the biosciences. The field of computational systems biology emerged from the need to integrate multicomponent biological systems and establish missing functional links among
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