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Series Editor Thomas Jue University of California Davis Davis, California

For other titles published in this series, go to www.springer.com/series/7845

Thomas Jue Editor

Biomedical Applications of Biophysics

Volume 3

Editor Thomas Jue, Ph.D. Department of Biochemistry and Molecular Medicine University of California Davis One Shields Avenue Davis, CA 95616, USA [email protected]

ISBN 978-1-60327-232-2 e-ISBN 978-1-60327-233-9 DOI 10.1007/978-1-60327-233-9 Springer New York Dordrecht Heidelberg London Library of Congress Control Number: 2010932766

© Springer Science+Business Media, LLC 2010 All rights reserved. This work may not be translated or copied in whole or in part without the written permission of the publisher (Humana Press, c/o Springer Science+Business Media, LLC, 233 Spring Street, New York, NY 10013, USA), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights. While the advice and information in this book are believed to be true and accurate at the date of going to press, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Humana Press is part of Springer Science+Business Media (www.springer.com)

PREFACE In the Biomedical Applications of Biophysics, Volume 3 of the Handbook of Modern Biophysics, the authors have added to the topics introduced in Volume 1, Fundamental Concepts in Biophysics. These additional topics help trace the broad field of biophysics. Patrice Koehl starts the book with an introduction to protein structure prediction based on energetics, homology modeling, and ab-initio calculations. Dickey and Faller follow with a “how-to approach” to model biomembranes. Brynda and Ames present the principles of magnetic resonance techniques, which researchers often use to solve protein and biomembrane structure. Brynda encapsulates the theoretical and methodological concepts of electron paramagnetic resonance spectroscopy. James Ames covers correspondingly the theory and application of biomolecular NMR spectroscopy. Because optical techniques can also reveal biomolecular structure, Jie Zheng discusses the commonly used fluorescence resonance energy transfer (FRET) in determining molecular distance. Chu and Lebrilla then turn their attention to a pivotal method of analytical chemistry, mass spectrometry. Green and Cheng show how transmission electron microscopy and computer-aided image processing can help visualize macromolecules in