Blood lipids and adipokines concentrations during a 6-month nutritional and physical activity intervention for metabolic
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RESEARCH
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Blood lipids and adipokines concentrations during a 6-month nutritional and physical activity intervention for metabolic syndrome treatment Frédéric Dutheil1,2,3, Bruno Lesourd1,2, Daniel Courteix1, Robert Chapier4, Eric Doré1, Gérard Lac1*
Abstract Background: To report changes in body weight, total and central fat mass, metabolic, hormonal and inflammatory parameters in overweight people who participated in a six months weight loss intervention associating diet management and exercise. Subjects and Methods: Fourteen subjects (10 M, 4 F, mean age 62.9 ± 6.9 years, BMI 30.4+/- 3.8 kg/m2) presenting the characteristics of the Metabolic Syndrome (MS) were included in the survey. They followed a three weeks (D0 to D20) cure in a medical establishment and a six months (D20 to M3 and M6) follow up at home. During the cure, they receive a balanced diet corresponding to 500 Kcal deficit vs their dayly energy expenditure (DEE) and they exercised 2 to 3 hours per day. At D0, D20, M3 and M6, body composition (lean mass, total and central fat mass) was analyzed with DEXA, blood pressure was taken and blood was collected to evaluate glycaemia, triglycerides, total, LDL and HDL cholesterol, insulin, leptin and adiponectin levels, CRP and pro-inflammatory interleukines IL1, IL.6 and TNFalpha. Results: All parameters listed above except the cytokine were improved at D20, so that 4 subjects among 14 still presented the MS. After returning to home, these parameters remained stable. Conclusion: The efficacy of therapeutic lifestyle modifications with education and exercise and diet was demonstrated, but the compliance to the new healthy lifestyle initiated during the cure was not optimal.
Introduction Increase of body mass index (BMI) is a major risk factor of metabolic illness [1], in relation to abdominal obesity [2]. Visceral fat, as reflected by waist circumference, is linked to a lot of metabolic abnormalities like impaired glucose tolerance, dyslipidemia, high blood pressure (BP). This metabolic profile, called metabolic syndrome (MS), is associated with an increased risk of cardiovascular diseases (CVD) and type 2 diabetes prevalence [3]. In developed countries, its prevalence is increasing and is mainly linked to obesity and age [4]. The International Diabete Federation (IDF) has defined MS criteria as the co-occurrence of any three of the five following abnormalities: abdominal obesity (waist circumference > 94 cm in men and > 80 in * Correspondence: [email protected] 1 Clermont University Blaise Pascal, BAPS, EA 3533, BP 10448, F 63000 Clermont-Ferrand, France Full list of author information is available at the end of the article
women), dyslipidemia (triglyceridemia > 1,5 mmol/l, HDL cholesterol < 0.4 g/l in men and < 0.5 g/l in women), BP > 130/85 and/or treatment, and fasting glycemia > 5.55 mmol/l and/or treatment [5]. MS is acknowledged as a major cardiovascular risk factor of morbidity and mortality [6,7]. Moreover, it is associated with other metabolic abnormalities as a chronic
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