Bone and Osteoarthritis
Bone and Osteoarthritis places emphasis on the molecular and cellular events that lead to osteoarthritis, stressing the role of subchondral bone, which distinguishes this from other books on the disease. A novel aspect is the attention given to the possib
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Volume 4
Series Editors Felix Bronner Professor Emeritus University of Connecticut Health Center Farmington, CT USA
Mary C. Farach-Carson Professor of Biological Sciences Department of Biological Sciences University of Delaware Newark, DE USA
Other titles in this series Vol. 1: Bone Formation Felix Bronner and Mary C. Farach-Carson (Eds.) Vol. 2: Bone Resorption Felix Bronner, Mary C. Farach-Carson, and Janet Rubin (Eds.) Vol. 3: Engineering of Functional Skeletal Tissues Felix Bronner, Mary C. Farach-Carson, and Antonios G. Mikos (Eds.) Vol. 4: Bone and Osteoarthritis Felix Bronner and Mary C. Farach-Carson (Eds.)
Felix Bronner and Mary C. Farach-Carson (Eds.)
Bone and Osteoarthritis
Felix Bronner, PhD Professor Emeritus University of Connecticut Health Center Farmington, CT USA Mary C. Farach-Carson, PhD Professor of Biological Sciences Department of Biological Sciences University of Delaware Newark, DE USA
British Library Cataloguing in Publication Data Bone and osteoarthritis. - (Topics in bone biology ; v. 4) 1. Osteoarthritis - Pathogenesis 2. Bone I. Bronner, Felix II. Farach-Carson, Mary C., 1958-616.7’223071 ISBN-13: 978-1-84628-513-4 e-ISBN-13: 978-1-84628-701-5 Library of Congress Control Number: 2007930210 Printed on acid-free paper © Springer-Verlag London Limited 2007 Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or transmitted, in any form or by any means, with the prior permission in writing of the publishers, or in the case of reprographic reproduction in accordance with the terms of licences issued by the Copyright Licensing Agency. Enquiries concerning reproduction outside those terms should be sent to the publishers. The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant laws and regulations and therefore free for general use. Product liability: The publisher can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature. 9 8 7 6 5 4 3 2 1 Springer Science+Business Media springer.com
Preface
Osteoarthritis (OA) is a progressive and debilitating disease that affects some two thirds of people older than 65 years. Yet how the disease arises and what cellular and molecular changes the cartilage cells undergo in the course of the disease is not well understood. In recent years, bone and bone changes have been invoked as causing or contributing to cartilage destruction. Moreover, clinical care of osteoarthritic patients often falls on orthopaedic surgeons, as when an arthritic hip needs replacement. It therefore seemed logical for the series Topics in Bone Biology to devote a volume to this disease and its relationship to bone and bone metabolism, particularl
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