Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second N
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ARTICLE
Cite as Nano-Micro Lett. (2020) 12:180 Received: 13 May 2020 Accepted: 7 August 2020 © The Author(s) 2020
https://doi.org/10.1007/s40820-020-00516-z
Boosting Chemodynamic Therapy by the Synergistic Effect of Co‑Catalyze and Photothermal Effect Triggered by the Second Near‑Infrared Light Songtao Zhang1,2, Longhai Jin4, Jianhua Liu4, Yang Liu1, Tianqi Zhang4, Ying Zhao1, Na Yin1, Rui Niu1, Xiaoqing Li1, Dongzhi Xue1, Shuyan Song1, Yinghui Wang1 *, Hongjie Zhang1,2,3 * * Yinghui Wang, [email protected]; Hongjie Zhang, [email protected] State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun 130022, People’s Republic of China 2 University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China 1
3 4
Department of Chemistry, Tsinghua University, Beijing 100084, People’s Republic of China Department of Radiology, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China
HIGHLIGHTS • The MoS2 nanosheets served as co-catalyst could reduce F e3+ ions with lower Fenton reaction activity into the highly reactive F e2+ ions, thereby boosting the production of hydroxyl radical (•OH) for high efficiency chemodynamic therapy (CDT). • The photothermal effect of M oS2 nanosheets motivated by second near-infrared light could further improve the treatment effectiveness by synergetic photothermal-enhanced CDT and photothermal therapy.
ABSTRACT In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT)
has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS2 nanocomposites modified by bovine serum albumin (FeO/MoS2-BSA) with boosted Fenton
reaction efficiency by the synergistic effect of co-catalyze and photo-
thermal effect of M oS2 nanosheets triggered by the second near-infrared
(NIR II) light. In the tumor microenvironments, the M oS2 nanosheets not e2+ ions by M o4+ ions only can accelerate the conversion of F e3+ ions to F
on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS2-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, ben-
efiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT. KEYWORDS Chemodynamic therapy; Fenton reaction; Co-catalysis; Photothermal effect; NIR II biowindows
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1 Introduction Nowadays, cancer is an illness which threatens the human health owing to its high mortality rate and recurrence rate [1, 2]. Several treatment strategies have been applied in clinic, such as surgery [3], radiotherapy [4], and chemotherapy [5, 6], but they still suffer from limited
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