Bordetella bronchiseptica : a rare cause of meningitis
- PDF / 496,973 Bytes
- 4 Pages / 595.276 x 790.866 pts Page_size
- 4 Downloads / 190 Views
CASE REPORT
Open Access
Bordetella bronchiseptica: a rare cause of meningitis Christopher Radcliffe1, Audun Lier2, Natnael Doilicho1, Sunil Parikh1,2 and Firas Kaddouh1,3*
Abstract Background: Bordetella bronchiseptica is a gram-negative, obligate aerobic coccobacillus known to cause disease in domesticated animals and pets. In humans, B. bronchiseptica commonly leads to respiratory infections like pneumonia or bronchitis, and animal contact usually precedes the onset of symptoms. Case presentation: We report a case of post-traumatic B. bronchiseptica meningitis without recent surgery in the setting of immunosuppression with a monoclonal antibody. Our case concerns a 77-year-old male with ulcerative colitis on infliximab who sustained a mechanical fall and developed a traumatic cerebrospinal fluid leak complicated by meningitis. He received meropenem then ceftazidime during his hospital course, and temporary neurosurgical drain placement was required. His clinical condition improved, and he was discharged at his baseline neurological status. Conclusions: B. bronchiseptica is an unusual cause of meningitis that may warrant consideration in immunocompromised hosts with known or suspected animal exposures. To better characterize this rare cause of meningitis, we performed a systematic literature review and summarized all previously reported cases. Keywords: Bordetella bronchiseptica, Infliximab, Meningitis, Emerging infections
Background First isolated in 1911 as the causative agent behind canine distemper [1], Bordetella bronchiseptica is a gramnegative, obligate aerobe known to cause disease in dogs, pigs, and several other animals [2]. In humans, animal contact is often the source of transmission, and respiratory infections like pneumonia or bronchitis are common clinical syndromes [2]. B. bronchiseptica infections often occur in people with immunocompromising conditions [3–9], and the majority of patients in a recent series had comorbidities which increased their susceptibility to infection [10].
Unlike respiratory infections, B. bronchiseptica meningitis is exceedingly rare [11–13]. We report a case of a 77-year-old male with ulcerative colitis on infliximab who sustained a fall and developed a traumatic cerebrospinal fluid (CSF) leak complicated by B. bronchiseptica meningitis. To our knowledge, this represents the first reported case of post-traumatic B. bronchiseptica meningitis in a patient without recent central nervous system instrumentation. We performed a systematic literature review and summarized all prior reports in order to better characterize this potentially emerging cause of meningitis.
* Correspondence: [email protected] 1 Yale School of Medicine, 15th York Street, LLCI 10th floor, P.O. Box 208018, New Haven, CT 06520, USA 3 Department of Neurology, Division of Neurocritical Care and Emergency Neurology, Yale New Haven Hospital, New Haven, CT, USA Full list of author information is available at the end of the article
Case presentation A 77-year-old male with a past medical history of h
Data Loading...
