Bortezomib
- PDF / 138,898 Bytes
- 1 Pages / 595.245 x 841.846 pts (A4) Page_size
- 54 Downloads / 158 Views
1
S
Ischaemic colitis and mesenteric ischaemia in an elderly patient: case report A 77-year-old woman developed ischemic colitis and mesenteric ischaemia during treatment with bortezomib. The woman, who had multiple myeloma, received her first treatment with bortezomib 2.2 mg/72h [route not stated] in June 2011. She also received dexamethasone. After her fourth dose, she presented to the emergency services with constipation and abdominal pain that she had been experiencing for several days. Bortezomib was suspended and she was admitted. A colonoscopy revealed red-stained abdundant faecal residue in her descending colon, surface ulcers, and diffuse mucous with black plaques, demonstrating severe ischaemic colitis. A CT scan revealed oedematous thickening of her colon wall with adjacent frayed fatty tissue. The woman was treated conservatively and progressed satisfactorily after 12 days. Bortezomib was restarted and she soon experienced nausea, abdominal distension, and vomited bile. She was diagnosed with chronic mesenteric ischaemia. She was discharged after a further 15 days. Lenalidomide was being tried as second-line therapy for her multiple myeloma. Author comment: "After applying the causality algorithms [Naranjo and Karch-Lasagna], the adverse reaction came out in both cases as definitively due to bortezomib (10 points)." Romero Soria L, et al. Ischaemic colitis associated with bortezomib: Case report. European Journal of Hospital Pharmacy - Science and Practice 19: 129, No. 2, Apr 803079245 2012. [abstract] - Spain
0114-9954/10/1426-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Reactions 3 Nov 2012 No. 1426
Data Loading...
