Botulinum Toxin Treatment of Pain Disorders
This book provides an authoritative overview of botulinum neurotoxin (BoNT) treatment menus for 14 pain categories with an evidence based literature review on each pain disorder, illustrative figures along with brief video clips showing the techniques and
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Botulinum Toxin Treatment of Pain Disorders
Bahman Jabbari
Botulinum Toxin Treatment of Pain Disorders
Bahman Jabbari Professor of Neurology and Director of Botulinum Toxin Treatment Program Yale School of Medicine New Haven, CT USA
ISBN 978-1-4939-2500-1 ISBN 978-1-4939-2501-8 DOI 10.1007/978-1-4939-2501-8
(eBook)
Library of Congress Control Number: 2015935243 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface
Very few pharmaceutical agents in medicine have shown efficacy for treatment of so many diverse categories of disorders as botulinum neurotoxins (BoNTs). BoNTs are useful in the treatment of involuntary movements (mostly dystonias), disorders of muscle tone (spasticity), autonomic derangements (sialorrhea and hyperhidrosis), and pain, to name a few. In the latter category, animal studies have provided clear evidence for the analgesic effect of BoNTs through a variety of mechanisms, most notable among them being inhibition of pain mediator release and antiinflammatory effects. With the emergence of controlled data on the efficacy of onabotulinum toxin A (and, more recently, other neurotoxins) in different kinds of human pain, it became clear that a textbook with updated clinical and research data in this field is needed, and such a book would be of value to both clinicians and researchers. The analgesic effect of BoNTs has been one of my areas of interest for the past 25 years, and I take credit for some of the earlier human studies in this field. At Yale, where I currently practice, several of our ongoing clinical trials are focused on this issue. The first chapter of this book briefly discusses the molecular structure, toxin types, mode of action, immunology, and side effects of currently available BoNTs. The pathophysiol
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