Brain metastasis
- PDF / 380,858 Bytes
- 5 Pages / 595.276 x 790.866 pts Page_size
- 40 Downloads / 210 Views
· L. Gerdan1, 2 · B. Segedin3 · V. Nagy4 · M.T. Khoa5, 6 · N.T. Trang6 · S.E. Schild7 1 Department of Radiation Oncology, University of Lübeck 2 Section of Nuclear Medicine, University of Lübeck 3 Department of Radiation Oncology, Institute of Oncology, Ljubljana 4 Department of Radiotherapy, Oncology Institute Ion Ciricuta, Cluj-Napoca 5 Department of Nuclear Medicine, Hanoi Medical University, Hanoi 6 Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi 7 Department of Radiation Oncology, Mayo Clinic Scottsdale
Brain metastasis Prognostic value of the number of involved extracranial organs
Brain metastases occur in 10–30% of all adult cancer patients during the course of their disease [5, 18]. The selection of the optimal treatment approach is likely to be influenced by the patient’s survival prognosis. The prognosis can be estimated with the help of prognostic factors and prognostic scores. Several significant prognostic factors have already been identified, and several prognostic scores already exist for patients with brain metastasis [3, 8, 12, 17]. The most relevant prognostic factors that have also been included in most scores are the patient’s performance status, age, and extracranial metastases.
Regarding extracranial metastases, the prognostic scores have included only the options “yes” or “no”. However, the number of extracranial organs involved by metastatic disease may also of independent prognostic significance and has not been investigated. The aim of the present study was to evaluate the potential prognostic role of the number and the type of extracranial organs involved with respect to survival. In order to reduce the risk of a selection bias, only patients who received whole-brain radiotherapy (WBRT) alone were included in this study. In order to further reduce the risk of bias, pa-
1.0
tients who received 37.5 Gy in 15 fractions or 40 Gy in 20 fractions were not included in this study, since a previous study has suggested that an escalation of the WBRT dose beyond 30 Gy in 10 fractions was associated with improved survival in patients with a favorable survival prognosis [14].
Materials and methods The data of 1146 patients with brain metastases who received WBRT alone with either 20 Gy in 5 fractions (n=393) or 30 Gy in 10 fractions (n=753) between
1.0
P
Data Loading...
