Brain Protection in Schizophrenia, Mood and Cognitive Disorders
Neuroprotection is a novel perspective for the treatment of disorders that lead to neurodegeneration and disabilities as a result of deterioration of neurons due to apoptosis, oxidative stress, excitotoxicity, and other mechanisms. These mechanisms have i
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Michael S. Ritsner Editor
Brain Protection in Schizophrenia, Mood and Cognitive Disorders
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Editor Michael S. Ritsner, MD, PhD Associate Professor of Psychiatry Rappaport Faculty of Medicine Technion – Israel Institute of Technology Haifa Chair, Acute Department Sha’ar Menashe Mental Health Center Hadera, Israel Board Member The International Journal of Neuroprotection and Neuroregeneration [email protected] [email protected]
ISBN 978-90-481-8552-8 e-ISBN 978-90-481-8553-5 DOI 10.1007/978-90-481-8553-5 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010921796 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Foreword
Neuroprotection is a novel perspective for the treatment of Alzheimer’s, Parkinson’s, and Huntington’s disorders that lead to neurodegeneration and disabilities as a result of deterioration of neurons due to apoptosis, oxidative stress, excitotoxicity, and other mechanisms. Since these mechanisms have implications not only for neurodegenerative disorders, but also for schizophrenia, mood and cognitive disorders, a synthesis of findings from neuroscience and clinical research across these disorders is warranted. We are now faced with the challenge to translate these new findings into therapeutic advantages. The purpose of this book is to provide an up-to-date overview of basic and clinical studies concerning the neuroprotective approach, mechanisms, several compounds with neuroprotective properties, nanotechnological scientific advances and neuromodulatory techniques that may contribute to more efficacious treatment of major mental health disorders. The book is divided into two parts. The first part serves as an introduction and overview of conceptual issues of the neuroprotective approach, and some neurobiological advances. Chapters in this part review definitions, perspectives, and issues that provide a conceptual base for the rest of the book. In addition, this part includes chapters in which the authors present and discuss the findings from basic studies of neurodegenerative mechanisms that are associated with the pathogenesis of major mental health disorders. The second part focuses on findings obtained from clinical trials with neuroprotective compounds, and neuromodulatory techniques. The takehome message is that principles of the neuroprotective approach may be applied to treatment of schizophrenia, mood and cognitive disorders. Contributors to this book are among the most active investigators and clinicians in the field who provide new perspectives
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