Braylin induces a potent vasorelaxation, involving distinct mechanisms in superior mesenteric and iliac arteries of rats
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ORIGINAL ARTICLE
Braylin induces a potent vasorelaxation, involving distinct mechanisms in superior mesenteric and iliac arteries of rats W. A. Santos 1 & K. M. C. Dourado 1 & F. A. Araújo 2 & R. L. C. Jesus 1 & R. A. Moraes 1 & S. C. D. S. Oliveira 1 & Q. L. Alves 1 & L. O. Simões 1 & L. L. Casais-e-Silva 1 & R. S. Costa 3 & E. S. Velozo 3 & D. F. Silva 1,2 Received: 12 May 2020 / Accepted: 4 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Arterial hypertension is a risk factor for various cardiovascular and renal diseases, representing a major public health challenge. Although a wide range of treatment options are available for blood pressure control, many hypertensive individuals remain with uncontrolled hypertension. Thus, the search for new substances with antihypertensive potential becomes necessary. Coumarins, a group of polyphenolic compounds derived from plants, have attracted intense interest due to their diverse pharmacological properties, like potent antihypertensive activities. Braylin (6-methoxyseselin) is a coumarin identified in the Zanthoxylum tingoassuiba species, described as a phosphodiesterase-4 (PDE4) inhibitor. Although different coumarin compounds have been described as potent antihypertensive agents, the activity of braylin on the cardiovascular system has yet to be investigated. To investigate the vasorelaxation properties of braylin and its possible mechanisms of action, we performed in vitro studies using superior mesenteric arteries and the iliac arteries isolated from rats. In this study, we demonstrated, for the first time, that braylin induces potent vasorelaxation, involving distinct mechanisms from two different arteries, isolated from rats. A possible inhibition of phosphodiesterase, altering the cyclic adenosine monophosphate (cAMP)/cAMP-dependent protein kinase (PKA) pathway, may be correlated with the biological action of braylin in the mesenteric vessel, while in the iliac artery, the biological action of braylin may be correlated with increase of cyclic guanosine monophosphate (cGMP), followed by BKCa, Kir, and Kv channel activation. Together, these results provide evidence that braylin can represent a potential therapeutic use in preventing and treating cardiovascular diseases. Keywords Braylin . Coumarin . Vasodilation . Mesenteric artery . Iliac artery . Hypertension
Introduction Cardiovascular diseases (CVD) are currently considered the main cause of death worldwide. According to an estimation from the World Health Organization (WHO), more than 20 million people will die because of these pathologies in 2030 (Mendis et al. 2007; Mendis 2017). Arterial hypertension has
* D. F. Silva [email protected]; [email protected] 1
Laboratory of Cardiovascular Physiology and Pharmacology, Federal University of Bahia, Avenida Reitor Miguel Calmon, Vale do Canela, Salvador, Bahia 40110-902, Brazil
2
Gonçalo Moniz Institute, Oswaldo Cruz Foundation – FIOCRUZ, Rio de Janeiro, Bahia, Brazil
3
Faculty of Pharmacy, Federal University of Bahia, Sa
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