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Lack of efficacy: case report An 8 years and 10-month-old boy exhibited lack of efficacy while being treated with brivaracetam, lacosamide and valproic acid for complex partial seizures. The boy, who had complex partial seizures started receiving brivaracetam, lacosamide and valproic acid, along with vagus nerve stimulation. However, his seizures were found to be refractory. Later on, he was found to have neurodevelopmental disorder with secondary macrocephaly and epilepsy due to de novo PAK1 missense variant. Ohori S, et al. A novel PAK1 variant causative of neurodevelopmental disorder with postnatal macrocephaly. Journal of Human Genetics 65: 481-485, No. 5, May 2020. 803504430 Available from: URL: http://doi.org/10.1038/s10038-020-0728-8

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Reactions 3 Oct 2020 No. 1824