Burden of migraine among Japanese patients: a cross-sectional National Health and Wellness Survey
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(2020) 21:110
The Journal of Headache and Pain
RESEARCH ARTICLE
Open Access
Burden of migraine among Japanese patients: a cross-sectional National Health and Wellness Survey Shoji Kikui1, Yirong Chen2, Hiroshi Todaka3, Keiko Asao3, Kenji Adachi3 and Takao Takeshima1*
Abstract Background: Limited studies have measured the burden of migraine in Japan. This study aimed at estimating the disease burden of migraine in Japan and identifying factors associated with the burden using the 2017 National Health and Wellness Survey. Methods: Migraine patients were defined by ICHD-3 like criteria with ≥4 monthly headache days (MHDs), and nonmigraine respondents were selected using 1:4 propensity score matching. Multivariate analyses were conducted to compare Health-related Quality of Life (HRQoL), work productivity and activity impairment (WPAI), healthcare resource utilization (HRU) and costs between the two groups, and to identify factors associated with these outcomes in migraine patients. Results: In 30,001 respondents, 378 migraine patients were identified. Compared to matched controls (N = 1512), migraine patients had lower physical (45.17 vs. 49.89), mental (42.28 vs. 47.71) and role/social (37.91 vs. 44.19) component summary scores (p < 0.001). Migraine patients had higher absenteeism (6.4% vs. 2.2%), presenteeism (40.2% vs. 22.5%), total work productivity impairment (44.3% vs. 24.5%), total activity impairment (45.0% vs. 23.9%), indirect costs (1,492,520 JPY vs. 808,320 JPY) and more visits to healthcare providers in the past 6 months (7.23 vs. 3.96) (p < 0.001). More MHDs was associated with worse HRQoL, and higher HRU and indirect costs. Conclusions: Japanese migraine patients experience an incremental burden. This demonstrates the unmet needs among Japanese migraine patients. Keywords: Migraine, Health-related quality of life, Work productivity, Healthcare resource utilization, Costs, Economic burden
Background The importance of understanding the burden of illness associated with migraine is becoming increasingly recognized, both as part of clinical trials and health technology assessment [1]. This includes measuring the burden of disease by use of patient reported outcome tools such as health-related quality of life (HRQoL), the impact of * Correspondence: [email protected] 1 Department of Neurology & Headache Center, Tominaga Hospital, 1-4-48 Minatomiachi, Naniwa-ku, Osaka 556-0017, Japan Full list of author information is available at the end of the article
illness on work productivity and the associated economic burden [1]. The evaluation of how migraine affects patients’ lives from their perspective is useful for identifying therapeutic areas of need and providing guidance for development of future treatment [2, 3]. It has been well established that migraine is associated with burden for both patients and society worldwide [4– 7]. The global burden of disease calculation from 2016 ranked migraine as the second leading cause of years of life lived with disability (YLD) accounting for 5.6% of total YL
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