Burden of prediabetes, undiagnosed, and poorly or potentially sub-controlled diabetes: Lolland-Falster health study
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(2020) 20:1711
RESEARCH ARTICLE
Open Access
Burden of prediabetes, undiagnosed, and poorly or potentially sub-controlled diabetes: Lolland-Falster health study Neda Esmailzadeh Bruun-Rasmussen1* , George Napolitano2, Allan Kofoed-Enevoldsen3, Stig Egil Bojesen4, Christina Ellervik5,6, Knud Rasmussen5, Randi Jepsen1 and Elsebeth Lynge1
Abstract Background: This study aimed to investigate prevalence and risk factors for prediabetes, undiagnosed diabetes mellitus, poorly and potentially sub-controlled diabetes in a rural-provincial general adult population in Denmark. Methods: Using cross-sectional data from the Lolland-Falster Health Study, we examined a total of 10,895 individuals aged 20 years and above. Results: Prevalence of prediabetes was 5.8% (men: 6.1%; women: 5.5%); of undiagnosed diabetes 0.8% (men: 1.0%; women: 0.5%); of poorly controlled diabetes 1.2% (men: 1.5%; women: 0.8%); and of potentially sub-controlled diabetes 2% (men: 3.0%; women: 1.3%). In total, 9.8% of all participants had a diabetes-related condition in need of intervention; men at a higher risk than women; RR 1.41 (95% CI 1.26–1.58); person aged + 60 years more than younger; RR 2.66 (95% CI 2.34–3.01); obese more than normal weight person, RR 4.51 (95% CI 3.79–5.38); smokers more than non-smokers, RR 1.38 (95% CI 1.19–1.62); persons with self-reported poor health perception more than those with good, RR 2.59 (95% CI 2.13–3.15); low leisure time physical activity more than those with high, RR 2.64 (95% CI 2.17–3.22); and persons with self-reported hypertension more than those without, RR 3.28 (95% CI 2.93–3.68). Conclusions: In the Lolland-Falster Health Study, nearly 10% of participants had prediabetes, undiagnosed diabetes, poorly controlled, or potentially sub-controlled diabetes. The risk of these conditions was more than doubled in persons with self-reported poor health perception, self-reported hypertension, low leisure time physical activity, or measured obesity, and a large proportion of people with diabetes-related conditions in need of intervention can therefore be identified relatively easily. Keywords: Diabetes mellitus, Prediabetes, Undiagnosed diabetes, Glycaemic control, Lolland-Falster health study
Background Diabetes mellitus (DM) is a metabolic disease characterized by high blood glucose levels resulting from defects in insulin secretion, insulin action, or both [1]. It is one of the most prevalent chronic diseases worldwide affecting more than 451 million adults in 2017 with a * Correspondence: [email protected] 1 Center for Epidemiological Research, Nykøbing Falster Hospital, Strandboulevarden 64, DK-4800 Nykøbing Falster, Denmark Full list of author information is available at the end of the article
projected increase to 693 million by 2045 [2]. According to the International Diabetes Federation (IDF), more than 224 million adults with DM remain undiagnosed due to a combination of lack of awareness, poor health systems, slow onset of symptoms, and slow disease progression [2]. Undiagnosed, poorly or sub-controlled
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