C-phycocyanin Mitigates Cognitive Impairment in Doxorubicin-Induced Chemobrain: Impact on Neuroinflammation, Oxidative S
- PDF / 1,940,770 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 68 Downloads / 169 Views
BRIEF COMMUNICATION
C‑phycocyanin Mitigates Cognitive Impairment in Doxorubicin‑Induced Chemobrain: Impact on Neuroinflammation, Oxidative Stress, and Brain Mitochondrial and Synaptic Alterations Chenying Wang1,2 · Yuhang Zhao3 · Lewei Wang1 · Shunji Pan1 · Yumei Liu4 · Sanqiang Li5 · Dongmei Wang1 Received: 28 June 2020 / Revised: 26 October 2020 / Accepted: 28 October 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Chemotherapy-induced cognitive impairment (CICI) is a common detrimental effect of cancer treatment, occurring in up to 75% of cancer patients. The widely utilized chemotherapeutic agent doxorubicin (DOX) has been implicated in cognitive decline, mostly via cytokine-induced neuroinflammatory and oxidative and mitochondrial damage to brain tissues. C-phycocyanin (CP) has previously been shown to have potent anti-inflammatory, antioxidant, and mitochondrial protective properties. Therefore, this present study was aimed to investigate the neuroprotective effects of CP against DOX-elicited cognitive impairment and explore the underlying mechanisms. CP treatment (50 mg/kg) significantly improved behavioral deficits in DOX-treated mice. Furthermore, CP suppressed DOX-induced neuroinflammation and oxidative stress, mitigated mitochondrial abnormalities, rescued dendritic spine loss, and increased synaptic density in the hippocampus of DOX-treated mice. Our results suggested that CP improves established DOX-induced cognitive deficits, which could be explained at least partly by inhibition of neuroinflammatory and oxidant stress and attenuation of mitochondrial and synaptic dysfunction. Keywords C-phycocyanin · Chemotherapy · Cognitive · Mitochondria · Doxorubicin Abbreviations CICI Chemotherapy-induced cognitive impairment CP C-phycocyanin DOX Doxorubicin mPTP Mitochondrial permeability transition pore GSH Glutathione MM Mitochondrial membrane potential MDA Malondialdehyde * Sanqiang Li [email protected] * Dongmei Wang [email protected] 1
School of Basic Medical Sciences, Henan University of Science and Technology, Luoyang 471023, China
2
Department of Clinical Laboratory Science, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China
3
Hangzhou Medical College, Hangzhou, China
4
College of Animal Science and Technology, Henan University of Science and Technology, Luoyang, China
5
Henan Centre for Engineering and Technology Research On Prevention and Treatment of Liver Diseases, Luoyang, China
MWM Morris water maze PSD95 Postsynaptic density protein 95 ROS Reactive oxygen species SOD Superoxide dismutase
Introduction Advances in the efficacy of cancer treatment have contributed to a significantly reduced risk of recurrence and a sharp increase in patient survival rates. However, up to 75% of cancer patients have reported suffering from cognitive impairment during chemotherapy [1], sometimes lasting years after cessation of chemotherapy [2]. Chemotherapyinduced cognitive impairment (CICI), commonly re
Data Loading...
