Can Oocyte Diameter Predict Embryo Quality?
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REPRODUCTIVE ENDOCRINOLOGY: ORIGINAL ARTICLE
Can Oocyte Diameter Predict Embryo Quality? Rawad Bassil 1 & Robert F. Casper 1,2 & Jim Meriano 1 & Ramsey Smith 1 & Jigal Haas 1,3 & Chaula Mehta 1 & Raoul Orvieto 3 & Eran Zilberberg 1 Received: 14 March 2020 / Accepted: 25 August 2020 # Society for Reproductive Investigation 2020
Abstract With the recent increased utilization of oocyte vitrification for the purpose of fertility preservation, information regarding the future fertility potential of the frozen oocytes is mandatory. Nowadays, there is a relative lack of data about prediction of assisted reproductive technique (ART) success relying on the retrieved oocytes. In the present study, we therefore aimed to investigate whether oocyte diameter might predict the quality of the developing embryo. A retrospective, single-center cohort study. Oocytes retrieved following controlled ovarian hyperstimulation cycles during 2016 and incubated in a time-lapse incubator system were analyzed. Oocytes were grouped by mean oocyte diameter (MOD) and incubated for 5 days before the final morphological evaluation done by an expert embryologist. A total of 471 cycles which yielded 3355 metaphase II oocytes were included in the analysis. Embryos developed from oocytes with MOD close to the average (Average 1SD < MOD < Average + 1SD) had increased good-quality blastulation rates compared with embryos that developed from very small or very large oocytes. Oocytes with MOD between 105.96 and 118.69 μm have better probability of becoming top-quality D5 blastocysts (17.1–17.4% grade 1 embryos). There is a correlation between oocyte’s MOD and the embryo quality at day 5. The oocytes with near average MOD have a better chance to develop to a good-quality embryo. Therefore, the study suggests that MOD might serve as a predictor for embryo grading at day 5. Keywords In vitro fertilization . Intracytoplasmic sperm injection . Oocyte diameter . Blastocyst grading . Fertility preservation . ART . Vitrification
Introduction Controlled ovarian hyperstimulation (COH) in in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatment is used to recruit multiple metaphase II (MII) oocytes, since it is well established that the higher the number of oocyte retrieved, the higher the cumulative live birth rate (LBR) after utilizing all the cryopreserved embryos [1]. For oocytes to
* Eran Zilberberg [email protected] 1
TRIO Fertility Partners, Division of Reproductive Sciences, University of Toronto, 655 Bay St 11th floor, Toronto, ON M5G 2K4, Canada
2
Division of Reproductive Sciences, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
3
Infertility and IVF Unit, Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Aviv University, Tel Hashomer, Ramat Gan, Israel
achieve proper maturation, some intricate and synchronized processes need to be accomplished, including nuclear, epigenetic, and cytoplasmic maturation. Nowadays, the maturity and quality of MI
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