Cancer and Coronavirus Disease (COVID-19): Comorbidity, Mechanical Ventilation, and Death Risk
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REVIEW ARTICLE
Cancer and Coronavirus Disease (COVID-19): Comorbidity, Mechanical Ventilation, and Death Risk Mohammad Hossein Jarahzadeh 1 & Fatemeh Asadian 2 & Meraj Farbod 3 & Bahare Meibodi 4 & Hajar Abbasi 5 & Mohammadali Jafari 6 & Ali Raee-Ezzabadi 6 & Reza Bahrami 7 & Hossein Neamatzadeh 8,9 Accepted: 24 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background The presence of comorbidity poses a major clinical challenge in the care and treatment of COVID-19 patients. Moreover, having one or more comorbidities could be a life-threatening situation in COVID-19 patients. Cancer is substantially associated with significant morbidity and mortality in COVID-19 patients. However, there is not sufficient data to conclude that cancer patients have a higher risk of COVID-19 infection. In this study, we reviewed cancer comorbidity and risk of mechanical ventilation or death in patients with confirmed COVID-19. Methods A comprehensive systematic search was performed on PubMed, Scopus, Web of Science, SciELO, and CNKI, to find articles published until August 01, 2020. All relevant case series, case reports, systematic and narrative reviews, meta-analyses, and prospective and retrospective studies that reported clinical characteristics and epidemiological information of cancer patients infected with COVID-19 were included in the study. Results A total of 12 cohort studies exclusively on cancer patients with confirmed COVID-19 were selected. Conclusions According to the findings of this study, cancer was not among the most prevalent underlying diseases in patients with confirmed COVID-19. Moreover, cancer patients infected with COVID-19 had the lowest risk of mechanical ventilation or death than the non-cancer infected patients. Keywords COVID-19 . Cancer . Malignancy . Intensive care unit . Ventilation . Death
Introduction The severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) was first recognized in persons presenting with pneumonia of unknown etiology in Wuhan City, China, in December 2019 [1–3]. The World Health Organization (WHO) selected the official name of COVID-19 (stands for coronavirus disease 2019) for the disease [4, 5]. The new * Fatemeh Asadian [email protected] 1
Department of Anesthesiology and Critical Care, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2
Department of Medical Laboratory Sciences, School of Paramedical Science, Shiraz University of Medical Sciences, Shiraz, Iran
3
Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
4
Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
pandemic is a source of profound morbidity and mortality which caused by a novel single-strand RNA (ssRNA) betacoronavirus [6]. Compared with previous viral outbreaks, the COVID-19 pandemic has a relatively high mortality rate, the reasons for which are not entirely known [5, 6]. Analyzing the clinical and epidemiological data of patients with confirmed CO
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