Cancer Diagnosis Early Detection

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Edited by Peter Bannasch

With 49 Figures

Springer-Verlag Berlin Heidelberg New York London Paris Tokyo Hong Kong Barcelona Budapest

Prof. Dr. PETER BANNASCH

Abteilung fUr Cytopathologie Deutsches Krebsforschungszentrum 1m Neuenheimer Feld 280 W-6900 Heidelberg, FRG

The publication of this book was supported by the Arbeitsgemeinschaft der GroBforschungseinrichtungen (AGF). Institutions participating in the AGF-KoordinierungsausschuB Krebsforschung DKFZ Deutsches Krebsforschungszentrum Heidelberg GBF Gesellschaft fUr Biotechnologische Forschung Braunschweig GSF Gesellschaft fUr Strahlen- und Umweltforschung Neuherberg KF A Kernforschungsanlage Jiilich KfK Kernforschungszentrum Karlsruhe

ISBN-13 :978-3-540-54503-3 DOl: 10.1007/978-3-642-76899-6

e-ISBN-13 :978-3-642-76899-6

Library of Congress Cataloging-in-Publication Data. Cancer diagnosis:early detectionledited by Peter Bannasch. p. cm. Includes bibliographical references and index. ISBN-13:978-3-540-54503-3 1. Cancer- Diagnosis-Congresses. 2. Cancer- Prevention-Congresses. 3. Medical screeningCongresses. I. Bannasch, Peter. [DNLM: 1. Neoplasms-diagnosis-congresses. QZ241 C2138j RC270.C33 1992 616.99'4075-dc20 DNLM/DLC for Library of Congress 92-2201 CIP This work is subject to copyright. All rights arc reserved, whether the whole or part of the material is concerned, specifically the rights of translation, rcprinting, reusc of illustrations. recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law.

© Springer-Verlag Berlin Heidelberg 1992 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that" such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual casc the user must check such information by consulting the relevant literature. Typesetting: Best-set Typesetter Ltd., Hong Kong 21/3130-5 4 3'2 1 0 - Printed on acid-free paper

Preface

Early detection of cancer has been recognized as an important area of preventive medicine for quite some time. In a few sites, such as the cervix, the breast, and the skin, it has been shown beyond doubt that early detection and secondary prevention of cancer are realistic goals. However, the general success of this approach is limited and requires substantial additional effort in research and public health education. The present volume is based on an International Symposium on Cancer Diagnosis - Early Detection, which was organized by the Committee Coordinating Cancer Research in G