Cancer Gene Networks
This volume is a valuable and timely resource for a broad audience with interests in basic and translational cancer biology, cancer drug development, as well as in the practice of personalized oncology. Written in the highly successful Methods in Molecula
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Usha Kasid Robert Clarke Editors
Cancer Gene Networks
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cancer Gene Networks
Edited by
Usha Kasid and Robert Clarke Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia, USA
Editors Usha Kasid Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington District of Columbia USA
Robert Clarke Lombardi Comprehensive Cancer Center Georgetown University Medical Center Washington District of Columbia USA
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-6537-3 ISBN 978-1-4939-6539-7 (eBook) DOI 10.1007/978-1-4939-6539-7 Library of Congress Control Number: 2016954430 © Springer Science+Business Media New York 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A
Preface In recent years, the application of systems biology to increase our understanding of cancer has led to the integration of a variety of the state-of-the-art high-throughput and multidisciplinary tools and workflows. These advances have begun to reveal further some of the complexity, and the dynamic nature, of gene networks and signaling pathways that vary from tumor to tumor and also during the course of the disease. In this volume, a wide range of topics contributed by leading experts in the fields of cancer systems biology and therapeutics, medical bioinformatics, and computational biology offer both technical and methodological guidance and expert insights into many aspects associated with the study of cancer gene networks. Hence, this book provide
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