Cancer of the Oral Cavity, Pharynx and Larynx Evidence-Based Decisio

Written for residents and practitioners of otolaryngology, medical oncology, radiation oncology, and maxiollofacial surgery, this book provides the reader with a comprehensive, concise discussion of the best evidence available on which to base clinical de

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Evidence-Based Decision Making Jesus E. Medina Nilesh R. Vasan Editors

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Cancer of the Oral Cavity, Pharynx and Larynx

Jesus E. Medina • Nilesh R. Vasan Editors

Cancer of the Oral Cavity, Pharynx and Larynx Evidence-Based Decision Making

Editors Jesus E. Medina Department of Otolaryngology College of Medicine University of Oklahoma Oklahoma City, OK, USA

Nilesh R. Vasan Department of Otolaryngology College of Medicine University of Oklahoma Oklahoma City, OK, USA

ISBN 978-3-319-18629-0 ISBN 978-3-319-18630-6 DOI 10.1007/978-3-319-18630-6

(eBook)

Library of Congress Control Number: 2016948221 © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer International Publishing AG Switzerland

To my wife Libby, a constant source of inspiration! To my children Katherine, Joey and Kristine, their spouses and their children. They are our joy and pride. Jesus E. Medina, M.D. “To my wife Dimple and sons Dylan and Krish” Nilesh R. Vasan

Preface

The pursuit of knowledge is one of the fundamental pillars of medical professionalism. During the 8–10 years of medical education and residency training, physicians discipline themselves to acquire the knowledge needed to be able to diagnose and treat patients with different afflictions. The kind of knowledge we must pursue is described superbly by Sir William Osler, the late Regius Professor of Medicine at Oxford, in his book Aequanimitas: A knowledge of the fundamental sciences upon which our art is based, … not a smattering, but a full and deep acquaintance, not with all the facts, that is impossible, but with the great principles based upon them.

With the fast paced advances in medical technology and pharmacology, these principles evolve almost constantly, and we need to keep pace. Not too many years ago, conventional surgery and radiation therapy were the only treatment