Cancer Research and Clinical Trials in Developing Countries A Practi

This book describes the principles around which cancer research and clinical trials can be developed. Additionally, by describing the particularities of planning and implementing cancer research in developing countries, this book provides valuable practic

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A Practical Guide Daniela Cristina Stefan Editor

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Cancer Research and Clinical Trials in Developing Countries

Daniela Cristina Stefan Editor

Cancer Research and Clinical Trials in Developing Countries A Practical Guide

Editor Daniela Cristina Stefan, MD, PhD South African Medical Research Council, Francie van Zyl Parrow, Cape Town, South Africa

ISBN 978-3-319-18442-5 ISBN 978-3-319-18443-2 DOI 10.1007/978-3-319-18443-2

(eBook)

Library of Congress Control Number: 2015956613 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www.springer.com)

Dedicated to the millions who are in need of better health care through the progress of science.

Contents

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Introduction: The Need to Conduct Cancer Research in Developing Countries ......................................................................... Daniela Cristina Stefan Steps of a Research Study: From Research Question to Publication........................................................................................... Priya Ranganathan, Gouri Pantvaidya, C.S. Pramesh, and Rajendra A. Badwe

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Types of Research Designs ..................................................................... Fedor Moissenko, Cornelia Braicu, Ciprian Tomuleasa, and Ioana Berindan-Neagoe

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Clinical Trials in Developing Countries: An Overview ....................... Matthys Botha and Michèle Desire Zeier

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The Research Protocol ............................................................................ Gilberto Lopes, Gustavo Werutsky, and Patricia Moretto

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Ethics of Conducting Cancer Research in Developing Countries.................................................................................................. Jean Marie Kabongo Mpolesha, Mala Ali Mapatano, Ahmed Elzawawy, and Zan