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Various toxicities: 10 case reports In a retrospective study of 71 patients, who had been treated with mitomycin and capecitabine with concurrent radiotherapy between 2014 and 2019, 10 patients [ages and sexes not stated] were described, who developed thrombocytopenia (5 patients), diarrhoea (1 patient), ileus (1 patient), urethral stricture (1 patient), hydronephrosis (1 patient) or genitourinary toxicities (1 patient) during treatment with capecitabine and mitomycin for muscle-invasive bladder cancer. All the 10 patients, who had cT2-4aN0-2 M0 muscle-invasive bladder cancer, underwent transurethral resection of bladder tumour, which was followed by chemoradiation. The patients received radiotherapy in a 5-week schedule along with IV mitomycin [mitomcin-C] on day 1 (single dose) and oral capecitabine tablets 825 mg/m2 twice daily roughly 12 hours apart and within 30 minutes after a meal, excluding weekends [not all dosages stated]. The first daily dose of capecitabine was given one hour before radiotherapy. Eight of these 10 patients subsequently developed treatment-related grade 3–4 acute toxicities, manifested as thrombocytopenia (5 patients), diarrhoea (1 patient), ileus (1 patient) or two episodes of acute grade 3 genitourinary toxicities (1 patient); while the remaining two patients developed treatment-related grade 3–4 late onset toxicities, manifested as urethral stricture (1 patients) or hydronephrosis (1 patient) [durations of treatments to reactions onsets not stated]. In the above stated five patients, capecitabine was discontinued due to thrombocytopenia after 19 days (1 patient), 17 days (1 patient), 16 days (1 patient), 15 days (1 patient) or after 13 days (1 patient) of treatment, respectively. Other two of the remaining five patients discontinued capecitabine after 17 days of treatment due to diarrhoea (1 patient) or ileus (1 patient). The patient, who developed urethral stricture, required internal urethrotomy; while the other patient who developed hydronephrosis, required percutaneous nephrostomy [not all outcomes stated]. Voskuilen CS, et al. Radiation with concurrent radiosensitizing capecitabine tablets and single-dose mitomycin-C for muscle-invasive bladder cancer: A convenient alternative 803505467 to 5-fluorouracil. Radiotherapy and Oncology 150: 275-280, Sep 2020

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Reactions 10 Oct 2020 No. 1825