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Lack of efficacy: case report A 63-year-old man exhibited lack of efficacy during treatment with oxaliplatin and capecitabine for neuroendocrine tumour. The man was admitted due to persistent rectal bleeding for the last 3 weeks and constipation for the last 4 months. His medical history was significant for thyroid papillary carcinoma (diagnosed 15 years ago). Eventually, he was diagnosed with neuroendocrine tumour NET-G2 and active acromegaly (high IGF-I) with secondary type II diabetes. Subsequently, he underwent rectal resection with definitive colostomy. He started receiving palliative chemotherapy with oxaliplatin and capecitabine [dosages and routes not stated] for neuroendocrine tumour along with concomitant octreotide [Octreotide LAR] 20 mg/28 days. However, no response was observed with the first-line chemotherapy, even after three months of treatment. The man’s chemotherapy was therefore switched to cisplatin and etoposide. However, he eventually died [cause of death not stated]. Manuc T, et al. Metastatic neuroendocrine rectal tumor-case report. Journal of Gastrointestinal and Liver Diseases 27 (Suppl. 4): 9 abstr. 14, Nov 2018. Available from: URL: 803497705 https://www.jgld.ro/jgld/public/public/Supplements/supplement_2018_4.pdf [abstract]

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Reactions 22 Aug 2020 No. 1818