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Cutaneous adverse reaction: 6 case reports In a study conducted in South Korea, 6 patients including 3 men and 3 women aged 40–67 years were described, who developed serious cutaneous adverse reaction (SCAR) during antiepileptic treatment with carbamazepine, phenytoin or valproic-acid for pain control or seizure prevention [routes, dosages and durations of treatments to reactions onsets not stated]. All the patients had been receiving antiepileptic treatment with carbamazepine due to pain control (n=4), phenytoin (n=1) and valproic acid for seizure prevention following cranial haemorrhage operation (n=1). They developed SCAR secondary to the ongoing respective antiepileptic treatment with carbamazepine (n=4), phenytoin (n=1) and valproic-acid (n=1). Therefore, all the patients were hospitalised and received intensive care, and the antiepileptic treatments were stopped. Subsequently, they all recovered from SCARs. HLA-B alleles were found to be positive for all the patients. Lymphocyte activation test was positive for 5 patients, and negative for one patient. Kim E, et al. Antiepileptics-induced serious cutaneous adverse reactions and HLA-B alleles with lymphocyte activation tests in 6 Korean patients. European Journal of Human 803505940 Genetics 27 (Suppl. 1): 1028 abstr. E-P15.03, Jan 2019. Available from: URL: http://doi.org/10.1038/s41431-019-0408-3 [abstract]

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Reactions 10 Oct 2020 No. 1825