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Intestinal aspergillosis: case report A 46-year-old woman received ICE induction chemotherapy for acute myeloid leukaemia and developed intestinal aspergillosis. After 8 days of ICE [ifosfamide, carboplatin and etoposide; route, dosage and duration of treatment not stated] she had grade 4 neutropenia. She developed a fever and was started on empirical antibacterials, but had severe diarrhoea after 2 days of treatment. A different antibiotic regimen was trialled, but she progressed, with acute abdomen, septic shock and cardiorespiratory failure. She underwent right abdominal ileostomy, right colectomy, and received voriconazole. She improved rapidly, and the end of 2004 she had no signs of intestinal aspergillosis. Author comment: "Aspergillosis makes its way through the intestinal mucosa eventually disrupted by chemotherapy’s toxicity with consequent deterioration of gastro-intestinal immunity." Imola M, et al. Emergency hemicolectomy for intestinal primary aspergillosis in acute myeloid leukemia. Il Giornale di Chirurgia 33: 74-6, No. 3, Mar 2012 803077445 Italy

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Reactions 22 Sep 2012 No. 1420