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Fatigue, myelosuppression and kidney disease: case report A 73-year-old woman developed fatigue, myelosuppression and kidney disease during chemotherapy with carboplatin and pemetrexed for non-small cell lung cancer (NSCLC). The non-smoker woman, was diagnosed with stage IV NSCLC and had also developed clinical hypopituitarism. Hormonal assessment revealed presence of central hypothyroidism, diabetes insipidus, mild hyperprolactinemia and hypogonadotropic hypogonadism. Thus, a clinical suspicion of adrenal insufficiency was made. She had also been receiving dexamethasone and radiation therapy for NSCLC. Dexamethasone was being tapered. A neuroophthalmology evaluation showed a predominantly right temporal field defect likely caused by her suprasellar mass lesion, which had imaging evidence of chiasmal/prechiasmal compression on the right. Subsequently, she received 3 cycles of chemotherapy with pemetrexed and carboplatin [routes and dosages not stated]. Her NSCLC was stable overall on chemotherapy; however, she developed major cumulative side effects including myelosuppression, fatigue and kidney disease [durations of treatments to reactions onsets not stated]. The woman’s treatment with pemetrexed and carboplatin was discontinued [outcomes not stated]. Fan W, et al. Complete resolution of sellar metastasis in a patient with NSCLC treated with osimertinib. Journal of the Endocrine Society 3: 1887-1891, No. 10, Oct 2019. 803498304 Available from: URL: http://doi.org/10.1210/js.2019-00217

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Reactions 29 Aug 2020 No. 1819