Carboxymethyl cellulose-based wafer enriched with resveratrol-loaded nanoparticles for enhanced wound healing
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ORIGINAL ARTICLE
Carboxymethyl cellulose-based wafer enriched with resveratrol-loaded nanoparticles for enhanced wound healing Shabnam Amanat 1 & Somayeh Taymouri 1 & Jaleh Varshosaz 1 & Mohsen Minaiyan 2 & Ardeshir Talebi 3
# Controlled Release Society 2020
Abstract The present study aimed to prepare and investigate the wound healing potential of carboxymethyl cellulose (CMC)-based wafers incorporated with resveratrol (RSV)-loaded cellulose acetate butyrate (CAB) NPs. Accordingly, RSV-CAB NPs were prepared using the solvent evaporation method. The effect of different formulation parameters (polymer content, surfactant concentration, and the volume ratio of aqueous phase to organic phase) on the properties of NPs was investigated using the Box-Behnken design. Then, the optimized NPs were incorporated in wafers comprising CMC combined with hydroxyl propyl methyl cellulose (HPMC) or chitosan. Hydration capacity, porosity, adhesive strength, and hardness of the prepared nanocomposite wafers were examined. Optimized formulation was spherical, showing the particle size, polydispersity index, zeta potential, encapsulation efficiency %, drug loading %, and release efficiency % of 248.5 nm, 0.38, − 1.59, 87.58, 25.94, and 67.10, respectively. The CMC-HPMC wafers exhibited higher porosity, hydration capacity, and adhesive performance, as compared with the CMC wafers alone and CMC-chitosan wafers. Wound healing test and histological evaluation in the excisional wounds of the rats showed that the RSV-NPs-wafers were more effective as a healing accelerator, in comparison to wafers without drug or those containing the free RSV. These results demonstrated the potential of the RSV-NPs-wafer in wound healing drug delivery applications. Keywords Wound . Resveratrol . Cellulose acetate butyrate . Polymeric nanoparticles . In vitro drug release
Introduction Skin is often injured by wounding or physical trauma. Normally, the injured tissue of skin is able to repair itself via an intricate process that includes five stages: hemostasis, inflammation, migration, proliferation, and maturation. However, in certain cases, the healing process can be delayed Electronic supplementary material The online version of this article (https://doi.org/10.1007/s13346-020-00711-w) contains supplementary material, which is available to authorized users. * Somayeh Taymouri [email protected] 1
Department of Pharmaceutics, School of Pharmacy and Novel Drug Delivery Systems Research Centre, Isfahan University of Medical Sciences, PO Box 81745-359, Isfahan, Iran
2
Department of Pharmacology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
3
Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran
by several factors, putting the patients at a significant risk of long inflammation, increased tissue destruction, and necrosis [1]. Thus, it is important to design a mediated dressing to accelerate wound healing, as well as reducing the treatment cost. At present, many wound dressings are available i
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