Carcinogen Risk Assessment

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CONTEMPORARY ISSUES IN RISK ANALYSIS Sponsored by the Society for Risk Analysis Volume 1

RISK EVALUATION AND MANAGEMENT Edited by Vincent T. Covello, Joshua Menkes, and Jeryl Mumpower

Volume 2

DE MINIMIS RISK Edited by Chris Whipple

Volume 3

CARCINOGEN RISK ASSESSMENT Edited by Curtis C. Travis

Carcinogen Risk Assessment Edited by

Curtis C. Travis Oak Ridge National Laboratory Oak Ridge, Tennessee

Plenum Press • New York and London

Library of Congress Cataloging in Publication Data Carcinogen risk assessment / edited by Curtis C. Travis. p. cm. -(Contemporary issues in risk analysis; v. 3) Includes bibliographical references and index. ISBN-13: 978-1-4684-5486-4 e-ISBN-13: 978-1-4684-5484-0 DOl: 10.1007/978-1-4684-5484-0 I. Carcinogenicity testing. 2. Health risk assessment. 3. Cancer-Prevention. I. Travis, C. C. II. Series. RC268.65.C365 1988 87-37403 616.99'4071-dcl9 CIP

© 1988 Plenum Press, New York Softcover reprint of the hardcover lst edition 1988 A Division of Plenum Publishing Corporation 233 Spring Street, New York, N.Y. 10013 All rights reserved No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher

Contributors

Elizabeth L. Anderson

Clement Associates, Inc., Fairfax, Virginia 22031.

Edward J. Calabrese Environmental Science Program, School of Public Health, University of Massachusetts, Amherst, Massachusetts 0 I 003 Gail Charnley

Clement Associates, Inc., Fairfax, Virginia 22031

Vincent T. Covello D.C. 20550

Risk Assessment Program, National Science Foundation, Washington,

E. A. C. Crouch

Energy and Environmental Policy Center, Harvard University, and Metasystems, Cambridge, Massachusetts 02138

W. Gary Flamm Office of Toxicological Sciences, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204 Ronald W. Hart National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079 Holly A. Hattemer-Frey Office of Risk Analysis, Health and Safety Research Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831-6109 Graduate School of Industrial Administration, Carnegie-Mellon University, Lester B. Lave Pittsburgh, Pennsylvania 15213 Donald Mackay IA4, Canada

Institute for Environmental Studies, University of Toronto, Toronto M5S

Sally Paterson IA4, Canada

Institute for Environmental Studies, University of Toronto, Toronto M5S

Frederica P. Perera Division of Environmental Science, School of Public Health, Columbia University, New York, New York 10032 Robert J. Scheuplein Office of Toxicological Sciences, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, D.C. 20204 Paul Siovic

Decision Research, Eugene, Oregon 97401

Todd W. Thorslund

Clement Associates, Inc., Fairfax, Virginia 22031

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Contributors

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Curtis C. Travis Office of Risk Analysis, Health and Safety Research Divis