Cardiac Cellular Electrophysiology
Cardiac Cellular Electrophysiology is intended for the clinical cardiologist who wishes to refresh or deepen his understanding of the cellular basis of cardiac electrophysiology, for researchers interested in the basis of the electrical activity of the he
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BASIC SCIENCE FOR THE CARDIOLOGIST 1.
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ISBN 0-7923-7362-6
KLUWER ACADEMIC PUBLISHERS - DORDRECHT/BOSTON/LONDON
CARDIAC CELLULAR ELECTROPHYSIOLOGY
by Edward Carmeliet and Johan Vereecke
Department ofPhysiology K. UL. University Leuven Belgium
SPRINGER SCIENCE+BUSINESS MEDIA, LLC
Library of Congress Cataloging-in-Publication Data
ISBN 978-1-4613-5692-9 ISBN 978-1-4615-1715-3 (eBook) DOI 10.1007/978-1-4615-1715-3
Copyright © 2002 by Springer Science+Business Media New York Originally published by Kluwer Academic Publishers in 2002 Softcover reprint ofthe hardcover Ist edition 2002 Ali rights reserved. No part ofthis publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, mechanical, photocopying, recording, or otherwise, without the prior written permis sion of the publisher, Springer Science+Business Media, LLC. Printed on acid-free paper.
The Publisher offers discounts on this book for bulk purchases. information, send email to[[email protected]}
For further
Dedicated to Prof. Silvio Weidmann
and in memory of Prof. Edouard Coraboeuf
Contents
Acknowledgements Preface General description of electrical activity Ionic basis of resting and action potential
7
Excitability, pacemaking and conduction
67
Ionic currents and action potentials in cardiac cells
95
Modulation of electrical activity
179
Electrophysiological basis of the electrocardiogram
229
Acute ischaemia
253
Arrhythmias
279
Remodeling
307
References
331
Abbreviations
407
Index
411
Acknowledgements For copyright permission to reproduce figures we should like to thank the following publishers or societies: Acad Press: IV. 13, IV.l7, IV.29, IV.3I, IV.32, V.24, V.28, V.29. Am Physiol Soc: 1.4, IV.5, IV.6, IV.9, IV.12, IV.20, IV.24, V.S, V.18, V.20, V.26, V.30, V.32, VII.20, VII.22. Am Soc Clin Invest: V.33. Am Soc Pharmacol Exp Ther: IV.I4. Brit Med J Pub Co: V.2. Cambridge University Press, The Physiological Society: 11.16, IV.I, IV.3, IV.4, IV.7, IV.9, IV.10, IV.lS, IV.I9, IV.23, IV.27, IV.28, IV.30, IV.38, IV.39, V.3, V.IO, V.I2, VIII.lS. Can Cardiovasc Soc: VII.6. Ed. J.B. Bailliere: VIII.I7. Elsevier: 1.3, VII.I2, VII.IS, VII.I7,
