Cardiac magnetic resonance assessed valve morphology and aortic distensibility in severe aortic stenosis
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Cardiac magnetic resonance assessed valve morphology and aortic distensibility in severe aortic stenosis Christopher D Steadman*, Gerry P McCann From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Summary We have shown that cardiac magnetic resonance (CMR) can accurately assess aortic valve morphology in severe aortic stenosis (AS) and this is associated with significant differences in aortic distensibility (AD) despite similar degrees of stenosis severity. Background AD is known to be a prognostic marker in other diseases. The effect of valve morphology on AD has not been reported in patients with severe AS without coronary artery disease. Methods 46 patients with severe AS without obstructive coronary artery disease awaiting aortic valve replacement were studied. Transthoracic echocardiography (TTE) was used to assess aortic valve area using the continuity equation, peak aortic velocity and mean valve gradient. CMR was used to assess aortic valve morphology and to enable planimetry of aortic valve area. Two SSFP cines of the aortic valve were taken; one planned from a 3chamber cine at the level of the aortic annulus in enddiastole and one at the aortic valve tips in end-systole. The smallest planimetered valve area was used for analysis. A high temporal resolution cine of the ascending aorta was taken at the level of the pulmonary artery bifurcation with three blood pressure recordings taken at the same time; the average of the three readings was used for analysis. AD was calculated according to the formula (aortic area max - aortic area min/ aortic area max)*(systolic BP - diastolic BP).
Results Baseline characteristics; Males 74%, CMR aortic valve area 0.76±0.21 cm2 TTE aortic valve area 0.86±0.22 cm2, peak velocity 4.4±0.6m/s and mean gradient 48.5 ±14.1mmHg. AD was not normally distributed therefore was log transformed before analysis. The valve morphology could be clearly seen in all patients. More than half of the patients (63%) studied had bicuspid aortic valves, see Table 1. The bicuspid valves were classified as either Type 1 (fusion of right and left coronary cusps), Type 2 (fusion of right and non-coronary cusps), or Type 3 (fusion of left and non-coronary cusps). Of the 22 bicuspid valves with a raphe 14 were Type 1, eight Type 2 and no Type 3, of the seven without a raphe five were Type 1, two Type 2 and no Type 3. Valve morphology did not significantly correlate with valve area (TTE or CMR) or velocities/gradients. AD was not correlated with sex, age, aortic valve areas (CMR or TTE) or velocities/gradients. AD significantly decreased from trileaflet to bicuspid valve with raphe present and then further to bicuspid valve with raphe absent (ANOVA p=0.01), Figure 1. Conclusions CMR is uniquely placed to assess aortic valve morphology and assess vascular function. We have demonstrated that significant numbers of severely stenosed aortic valves are functionally bicuspid and that these valves are associated with impaired vascular function when c
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