Cardioprotection Against Acute Myocardial Infarction
This book will provide readers with a detailed understanding of the ischemic damage to the myocardium after myocardial infarction, as well as essential tools for the treatment of damaged heart after myocardial infarction. It discusses various method
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Cardioprotection Against Acute Myocardial Infarction
Shinya Minatoguchi
Cardioprotection Against Acute Myocardial Infarction
Shinya Minatoguchi Head of Heart Failure Center, Gifu Municipal Hospital Emeritus Professor, Gifu University Graduate School of Medicine Gifu, Japan
ISBN 978-981-15-0165-4 ISBN 978-981-15-0167-8 (eBook) https://doi.org/10.1007/978-981-15-0167-8 © Springer Nature Singapore Pte Ltd. 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Preface
Acute myocardial infarction (AMI) is caused by sudden coronary artery occlusion. Occlusion of the coronary artery, which provides blood flow and delivers oxygen and nutrients to the myocardial tissue, results in necrosis of the cardiac tissue. AMI frequently leads to heart failure because of a deteriorated left ventricular (LV) function and LV remodeling and is associated with high mortality [1]. The first-line and best treatment of acute myocardial infarction is reperfusion of the occluded coronary artery by percutaneous coronary intervention (PCI) as soon as possible. However, in a clinical setting, since it is often difficult to reperfuse the occluded coronary artery early enough to avoid damage and necrosis of the myocardium, cardioprotective strategies to minimize the damage of the myocardium caused by myocardial infarction are required. I have been interested in cardioprotection against acute myocardial infarction for more than 20 years and tried to find cardioprotective strategies to prevent LV remodeling and reduce the morbidity and mortality associated with heart failure. This monograph focuses on cardioprotection by (1) ischemic preconditioning, (2) pharmacological preconditi
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