Catalytic RNA
In recent years, unprecedented advances in many aspects of the molecular biology of nucleic acids have been witnessed. The area of RNA chemistry has undergone a kind of explosion, with a huge interest in RNA-mediated catalysis. At the same time, our struc
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Vol. 10
Series Editors F. Eckstein D. M. J. Lilley
Springer Berlin Heidelberg New York Barcelona Budapest Hong Kong London Milan Paris Santa Clara Singapore Tokyo
Fritz Eckstein . David M.J. Lilley (Eds.)
Catalytic RNA 1st edition 1996 . 2nd printing 1997
With 102 Figures, 11 of Them in Color Indices Volumes 6-10
Springer
Professor Dr. FRITz EcKSTEIN Max-Planck-Institut fUr Experimentelle Medizin Hermann-Rein-Stra8e 3 37075 Gottingen, Germany Professor DAVID M. J. LILLEY University of Dundee Biochemistry Department DundeeDDl4HN United Kingdom
ISSN 0933-1891 ISBN-13:978-3-S40-62679-4 DOl: 10.1007/978-3-642-61202-2
e- ISBN-13:978-3-642-61202-2
The Ubrary of Congress has catalogued this serial publication as follows: Ubrary of Congress Catalog Card Number 90-641817 This work is subject to copyright. All rights are reserved, whether the whole or part of the materi-
al is concerned, specifically the rights of translation, reprinting reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permissions for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. ©Springer-Verlag Berlin Heidelberg 1997 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Cover design: Design & Production, Heidelberg Typesetting: Best-set Typesetters Ltd., Hong Kong SPIN 10572520 39/3137/sPS - 5 4 3 2 I 0 - Printed on acid-free paper
Preface to the Series
This series examines new and exciting developments in molecular biology from the point of view what are arguably the most important players, the nucleic acids. Historically molecular biology developed as a series of interfaces, as geneticists met physicists, as structural chemists became interested in biology. This crossfertilisation is still a vital component of the subject, and this is reflected in these volumes where important new developments are reviewed from a perspective of structure and chemistry of nucleic acids. This goes to the heart of biology. For example, as the molecular genetics of development becomes clearer, we see that the process can be viewed as a control network resulting from a cascade of genes encoding DNA-binding proteins that go on to modulate further genes in the pathway. Thus in many respects this fundamental biological process comes down to the regulation of complex genetic systems by DNA-protein interactions. In the first decade of the series we have witnessed unprecedented advances in many aspects of the molecular biology of nucleic acids. The area of RNA chemistry has exploded since the series began, with the huge interest in RNA-mediated ca
