• PDF / 170,028 Bytes
• 1 Pages / 595.245 x 841.846 pts (A4) Page_size
• 69 Downloads / 150 Views

DOWNLOAD

REPORT

---

1 S

Hypertriglyceridaemia: case report A 74-year-old man developed hypertriglyceridaemia during treatment with propofol, norepinephrine, vasopressin and epinephrine. The man, who presented with fever and cough, was eventually diagnosed with corona virus disease-2019 (COVID-19). His medical history was significant for hypertension, stroke, end stage renal disease on haemodialysis, type 2 diabetes mellitus and anaemia. He was admitted to the ICU due to severe hypoxaemia. He was then intubated due to the critically illness. He started receiving propofol infusion for sedation and analgesia. He also started receiving multiple vasopressors like norepinephrine, vasopressin and epinephrine [dosages and routes not stated] due to septic shock. He also started receiving fentanyl drip concomitantly with propofol for sedation and analgesia. However, he developed multiorgan failure [aetiology not stated]. Therefore, continuous renal replacement therapy (CRRT) was initiated. On day 3 of hospitalisation, CRRT started to alarm negative pressure for the return line. Upon machine’s inspection, it was noted that the filter had a chocolate milk colour on the top and the tubing had chocolate milk coloured plasma in it. Serum triglyceride (TG) level was found to be significantly elevated (930 mg/dL). The man’s therapy with propofol was consequently discontinued. The following day, a repeat TG-level was found to be dropped to 321 mg/dL. Two days later, TG-level further dropped to 288 mg/dL. No further clotting was reported in the dialysis circuit thereafter. It was suspected that the hypertriglyceridaemia was caused by propofol in the presence of additional risk factors such as norepinephrine, vasopressin and epinephrine use and the underlying critical illness. Samal S, et al. Chocolate milk in CRRT circuit: Propofol induced hypertriglyceridemia. American Journal of the Medical Sciences : 7 Aug 2020. Available from: URL: http:// doi.org/10.1016/j.amjms.2020.08.003 803507776

0114-9954/20/1826-0001/$14.95 Adis © 2020 Springer Nature Switzerland AG. All rights reserved

Reactions 17 Oct 2020 No. 1826