CD49a + CD49b + NK cells induced by viral infection reflect an activated state of conventional NK cells
- PDF / 2,312,726 Bytes
- 9 Pages / 595.276 x 793.701 pts Page_size
- 11 Downloads / 188 Views
+
CD49a CD49b NK cells induced by viral infection reflect an activated state of conventional NK cells 1,2
1,2
1,2
3
3
1,2
Wenhan Li , Jing Zhou , Xianwei Wang , Yuzhang Wu , Lilin Ye , Haiming Wei , 1,2 1,2* 1,2* Rui Sun , Zhigang Tian & Hui Peng 1
Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; 2 Institue of Immunology, University of Science and Technology of China, Hefei 230027, China; 3 Institute of Immunology, Third Military Medical University, Chongqing 400038, China Received November 1, 2019; accepted January 26, 2020; published online April 23, 2020
Natural killer (NK) cells are important innate effectors that play a pivotal role in the defense against tumors and infections and participate in regulating adaptive immunity. Recent studies have revealed phenotypic and functional heterogeneity of NK cells. + Here, using murine models of acute and chronic lymphocytic choriomeningitis virus infection, we observed that a CD49a + CD49b NK cell subset emerged in the liver and other tissues, and underwent vigorous expansion following viral infection, + + before progressively decreasing in cell number. These viral infection-induced CD49a CD49b NK cells displayed an activated + + and mature phenotype. Moreover, compared with liver-resident NK cells and conventional NK (cNK) cells, CD49a CD49b NK cells showed increased functional competence, as evidenced by higher amounts of IFN-γ production and stronger cytotoxic + + capabilities during viral infection. Generation of these CD49a CD49b NK cells was shown to be independent of the T-bet + + transcription factor. Adoptive transfer experiments revealed that cNK cells could convert into CD49a CD49b NK cells fol+ + lowing viral infection. Collectively, these results suggest that viral infection-induced CD49a CD49b NK cells represent a transiently activated state of cNK cells. NK cells, liver, viral infection, cell activation, effector function Citation:
+
+
Li, W., Zhou, J., Wang, X., Wu, Y., Ye, L., Wei, H., Sun, R., Tian, Z., and Peng, H. (2020). CD49a CD49b NK cells induced by viral infection reflect an activated state of conventional NK cells. Sci China Life Sci 63, https://doi.org/10.1007/s11427-019-1665-1
INTRODUCTION Natural killer (NK) cells are vital innate effector cells, playing a role in tumor immunosurveillance, viral clearance, and allograft rejection (Vivier et al., 2011; Yu et al., 2018). NK cell activity relies on a balance of activating and inhibitory signals delivered via an array of germline-encoded receptors (Sivori et al., 2019; Vivier et al., 2011). In addition to their pivotal role in innate immunity, NK cells also act as important regulators in adaptive immunity, either through *Corresponding authors (Zhigang Tian, email: [email protected]; Hui Peng, email: [email protected])
direct cytotoxicity to immune cells or through the secretion
Data Loading...
