Celiac disease does not influence markers of ovarian reserve in adolescent girls
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GYNECOLOGIC ENDOCRINOLOGY AND REPRODUCTIVE MEDICINE
Celiac disease does not influence markers of ovarian reserve in adolescent girls Cihan Comba1 · Atakan Comba2 · Hakan Yılmaz3 · Sakir V. Erdogan4 · Omer Demir5 Received: 13 May 2020 / Accepted: 23 June 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose The aim of the study was to determine whether celiac disease affects ovarian reserve assessed by antral follicle counting, ovarian volume, and anti-müllerian hormone in adolescent patients. Methods This case–control multicenter trial was performed from January 1, 2017 to May 31, 2018 and included 45 girls. On days 2–5 of the menstrual cycle, measurements of serum follicle stimulating hormone, luteinizing hormone, estradiol, prolactin, and anti-müllerian hormone were performed. Antral follicle counts and ovarian volumes were determined on the same day. Results Evaluation was made of 21 (47.7%) celiac patients with a mean age of 15.8 ± 1.3 years, and 24 (52.3%) healthy control subjects with a mean age of 16.2 ± 1.2. There was no difference between the groups in respect of right and left ovarian volumes (p = 0.790 and p = 0.670, respectively). Serum levels of anti-müllerian hormone of the celiac patients and controls were found comparable [(3.7 ± 2.9 (0.5–12) and 3.6 ± 1.8 (1.2–8.1)] ng/mL, respectively, p = 0.915). Conclusions Celiac disease may not affect the ovarian reserve determined with established ovarian reserve markers including antral follicle counting, ovarian volume, and anti-müllerian hormone in adolescent patients. Trial registration ClinicalTrials.gov identifier (NCT number): NCT04024449 https://clinicaltrials.gov/ct2/show/NCT04024449 Keywords Celiac disease · Anti-müllerian hormone · Adolescent · Follicle stimulating hormone · Antral follicle counts Abbreviations AMH Anti-müllerian hormone AFCs Antral Follicle Counts CD Celiac disease
* Cihan Comba [email protected] 1
Department of Obstetrics and Gynecology, University of Health Sciences, Sultangazi Haseki Training and Research Hospital, Uğur Mumcu, Belediye Sokak No: 7, 34265 Sultangazi/Istanbul, Turkey
2
Department of Pediatrics, Faculty of Medicine Training and Research Hospital, Hitit University, Corum, Turkey
3
Department of Radiology, Faculty of Medicine Training and Research Hospital, Hitit University, Corum, Turkey
4
Department of Obstetrics and Gynecology, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
5
Department of Obstetrics and Gynecology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey
E2 Estradiol FSH Follicle stimulating hormone GFD Gluten-free diet Kg Kilogram LH Luteinizing hormone Ml Milliliter mIU Mili international unit ng Nanogram PRL Prolactin pg Picogram
Introduction Celiac disease (CD) is a systemic autoimmune disease, which develops as a result of persistent sensitivity to gluten in the diet in individuals with a genetic predisposition, and manifests with intestinal and extra
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