Cell-Based Assays Using iPSCs for Drug Development and Testing
The volume presents a variety of protocols that will be useful to researchers working in the field of disease modeling, drug discovery, and the cell biology of various tissues. Chapters in this book cover topics such as requirements and preconditions for
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Carl-Fredrik Mandenius James A. Ross Editors
Cell-Based Assays Using iPSCs for Drug Development and Testing
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Cell-Based Assays Using iPSCs for Drug Development and Testing Edited by
Carl-Fredrik Mandenius Division of Biotechnology, Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, Sweden
James A. Ross Tissue Injury and Repair Group, University of Edinburgh, Edinburgh, UK
Editors Carl-Fredrik Mandenius Division of Biotechnology Department of Physics Chemistry and Biology (IFM) Linko¨ping University Linko¨ping, Sweden
James A. Ross Tissue Injury and Repair Group University of Edinburgh Edinburgh, UK
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-9476-2 ISBN 978-1-4939-9477-9 (eBook) https://doi.org/10.1007/978-1-4939-9477-9 © Springer Science+Business Media, LLC, part of Springer Nature 2019 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover Caption: Morphogenesis of hiPSC-derived endothelial cells. hiPSC derived endothelial cells (left image) forming micro tubes in matrigel (right image). Live cells were stained with DRAQ5™ (red, nuclear) and /or calcein AM (green). [Palakkan, Nanda & Ross] This Humana imprint is published by the registered company Springer Science+Business Media, LLC, part of Springer Nature. The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface In 2012 Shinya Yamanaka and John Gurdon were awarded the Nobel Prize for Physiology or Medicine for their work demonstrating that mature cells can be reprogrammed to a stem cell phenotype. John Gurdon’s key achievement in 1962 provided the first experimental ev
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