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Cite as Nano-Micro Lett. (2019) 11:100 Received: 4 September 2019 Accepted: 14 October 2019 © The Author(s) 2019

https://doi.org/10.1007/s40820-019-0330-9

Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications Yao Liu1,2, Jingshan Luo1,2, Xiaojia Chen3, Wei Liu4 *, Tongkai Chen1,2 * * Wei Liu, [email protected]; Tongkai Chen, [email protected] Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, People’s Republic of China 2 Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, People’s Republic of China 3 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, People’s Republic of China 4 Key Laboratory of Artificial Micro‑ and Nano‑Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Wuhan 430072, People’s Republic of China 1

HIGHLIGHTS • The recent progress on using cell membrane-coated nanoparticles for drug delivery, cancer treatment, vascular disease, immune modulation, and detoxification are summarized in this review. • The patent applications related to the cell membrane coating technology from the past 10 years are collected, the future challenges and trends pertaining to this technology are comprehensively discussed. • Unique properties of cell membrane-coated nanoparticles make it a promising strategy for biomedical applications and will make outstanding contributions to human health.

ABSTRACT  Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research

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biocompatibility but also achieve effective and extended circulation in vivo, allowing

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for the execution of targeted functions. Although cell membrane-coated NPs offer

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clear advantages, much work remains before they can be applied in clinical prac‑ py ra he ot

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membrane coating technology, and review the patent applications related to this

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of various cell membrane types. In addition, we collate model drugs used in cell

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and characterization techniques. Next, we focus on the functions and applications

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membrane coating technology, followed by a summary of the existing preparation

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tice. In this review, we first provide a comprehensive overview of the theory of cell

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those of the artificial inner core material. The coated NPs not only increase their

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membranes offer an opportunity to unite natural cell membrane properties with

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readily applicable to nanoscale biomedicine. Nanoparticles (NPs) coated with cell

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technology from the past 10 years. Finally, we survey future challenges and trends pertaining to this technology in an effort to provide a comprehensive overview of the future development of cell membrane coating technology. KEYWORDS  Cell membrane; Biomimetic nanoparticles; Cancer