Cellular Dust as a Novel Hope for Regenerative Cancer Medicine
Although stem cells have the most therapeutic potential, the advantages of regenerative medicine may be best provided using extracellular vesicles which also known in the past as “cellular dust.” These microparticles are substances released by cells and p
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Cellular Dust as a Novel Hope for Regenerative Cancer Medicine Motahareh Sheikh Hosseini, Peyvand Parhizkar Roudsari, Kambiz Gilany , Parisa Goodarzi, Moloud Payab , Akram Tayanloo-Beik , Bagher Larijani , and Babak Arjmand Abstract
Although stem cells have the most therapeutic potential, the advantages of regenerative medicine may be best provided using extracellular vesicles which also known in the past as “cellular dust.” These microparticles are substances released by cells and play a pivotal M. Sheikh Hosseini and P. Parhizkar Roudsari Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected]; Peyvand. [email protected] K. Gilany Reproductive Immunology Research Center, Avicenna Research Institute, ACECR, Tehran, Iran Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium Integrative Oncology Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran e-mail: [email protected]
role in pathophysiology of tumor progression and metastasis, thrombosis, and inflammation. Extracellular vesicles including exosomes and cell-derived microparticles supporting many physiological and disease processes which are relevant to immunology, hemostasis, thrombosis, neurobiology, cell signaling,
A. Tayanloo-Beik Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected] B. Larijani Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical sciences, Tehran, Iran e-mail: [email protected]
P. Goodarzi Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected]
B. Arjmand (*) Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
M. Payab Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected]
Metabolomics and Genomics Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran e-mail: [email protected]
M. Sheikh Hosseini et al.
angiogenesis, and cancer. While they have not any value for many years, this cellular dust has been studied and shows therapeutic properties similar to their mother cells (stem cells) but without their disadvantages. These vesicles do not divide, limiting the risk of cancer, and do not differentiate either. Therefore, they prevent tumor progression and development of poor function. Furthermore, it appears that they can be produced by a single donor for several patients, and ha
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