Cellular Osmolytes From Chaperoning Protein Folding to Clinical Pers
This book provides essential insights into improving protein folding/stability, which is a result of the balance between the intra-molecular interactions of protein functional groups and their interactions with the solvent environment.Even a subtle change
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lular Osmolytes
From Chaperoning Protein Folding to Clinical Perspectives
Cellular Osmolytes
Laishram Rajendrakumar Singh Tanveer Ali Dar Editors
Cellular Osmolytes From Chaperoning Protein Folding to Clinical Perspectives
Editors Laishram Rajendrakumar Singh University of Delhi Dr. B. R. Ambedkar Center for Biomedical Research New Delhi India
Tanveer Ali Dar Clinical Biochemistry University of Kashmir Srinagar Jammu and Kashmir India
ISBN 978-981-10-3706-1 ISBN 978-981-10-3707-8 (eBook) DOI 10.1007/978-981-10-3707-8 Library of Congress Control Number: 2017938881 © Springer Nature Singapore Pte Ltd. 2017 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Nature Singapore Pte Ltd. The registered company address is: 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore
Contents
1 Osmolyte System and Its Biological Significance���������������������������������� 1 Pratima Chaudhuri (Chattopadhyay), Naira Rashid, and Charu Thapliyal 2 Protein-Osmolyte Interactions: Molecular Insights ���������������������������� 35 Fasil Ali, Usma Manzoor, Mudasser Azam, and Naseem A. Ansari 3 Crosstalk Between Osmolytes and Cellular Chaperones: Examples in Saccharomyces cerevisiae�������������������������������������������������� 55 Anusha R. Pallapati, Eshita Das, and Ipsita Roy 4 Osmolytes Offset the Urea’s Effect on Protein Structure and Function�������������������������������������������������������������������������������������������� 77 Safikur Rahman, Jihyun Park, and Jihoe Kim 5 Osmolytes: Key Players in Regulating Protein Aggregation �������������� 97 Garima Chhabra, Nividh Chandra, and Rajaram Swaminathan 6 Modulation of Protein Aggregation/Fibrillation by Osmolytes���������� 121 Mohd Younus Bhat, Laishram R
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