Central Nervous System Metastases
This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives.Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic dise
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Central Nervous System Metastases
Manmeet Ahluwalia Philippe Metellus • Riccardo Soffietti Editors
Central Nervous System Metastases
Editors Manmeet Ahluwalia Brain Tumor and Neuro-Oncology Center Cleveland Clinic Cleveland OH USA Riccardo Soffietti Department of Neuro-Oncology University and City of Health and Science Hospital Turin Italy
Philippe Metellus Department of Neurosurgery and Neuro-Oncology Clairval Hospital Center Ramsay-Générale de Santé Marseille France Neurophysiopathology Institute Aix-Marseille Université Marseille France
ISBN 978-3-030-23416-4 ISBN 978-3-030-23417-1 (eBook) https://doi.org/10.1007/978-3-030-23417-1 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
Foreword
Brain metastases are one of the most challenging complications of cancer. Patients with cancer are living longer, and consequently, brain metastases are seen more often and from primaries not traditionally associated with brain metastases, such as prostate or endometrial cancer. These findings suggest that the central nervous system may be a sanctuary site for solid tumors, much in the way that it is for hematologic malignancies. If so, this suggests that microscopic tumor reaches the brain over the course of the disease, perhaps even by initial diagnosis, and therapies that may control the disease elsewhere can’t penetrate an intact blood-brain barrier and eradicate the tumor residing within the brain parenchyma. This can lead to the delayed appearance of brain metastases in some patients, and in others, the brain can be the sole or residual site of disease. The therapy of brain metastases has improved over the years, in part by becoming more focal,
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