Challenges, Current Trends, and Future Directions
Selected reaction monitoring mass spectrometry (SRM-MS) has been developed enormously over the past two decades as a powerful technique to efficiently determine target protein concentration across many biological/clinical samples in terms of specificity,
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Selected Reaction Monitoring Mass Spectrometry (SRM-MS) in Proteomics A Comprehensive View
Selected Reaction Monitoring Mass Spectrometry (SRM-MS) in Proteomics
Mahmud Hossain
Selected Reaction Monitoring Mass Spectrometry (SRM-MS) in Proteomics A Comprehensive View
Mahmud Hossain Sanofi Genzyme Framingham, MA, USA
ISBN 978-3-030-53432-5 ISBN 978-3-030-53433-2 (eBook) https://doi.org/10.1007/978-3-030-53433-2 © Springer Nature Switzerland AG 2020 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
To my academic mentors Richard D. Smith, PhD Battelle Fellow & Chief Scientist, Biological Sciences Division, Pacific Northwest National Laboratory (PNNL), Richland, WA, USA Professor Fred W. McLafferty Peter J.W. Debye Professor, Emeritus, Dept. of Chemistry, Cornell University, NY, USA Professor Patrick A. Limbach Vice President for Research & Professor of Chemistry, University of Cincinnati, OH, USA Professor J. Ricky Cox Anna S. Brown & Ruth B. Logan Endowed Chair, Dept. of Chemistry, Murray State University, Murray, KY, USA Professor Mustafizur Rahman (in memory of) Department of Biochemistry & Molecular Biology, University of Dhaka, Bangladesh
To my virtual mentors (for targeted proteomics, especially for SRM-MS) Professor Ruedi Aebersold Dept. of Biology, Institute of Molecular Systems Biology, ETH Zurich, Switzerland Steven A. Carr, PhD Senior Director of Proteomics, Institute Scientist, Broad Institute of MIT & Harvard, USA To my lifelong mentors (my parents) M. Amir Hossain & Fatema Begum Hopkinton, Massachusetts, USA
The end of one journey is simply the start of another. You have to see what you missed the first time, see again what you already saw, see in springtime what you
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