Changes in fundus autofluorescence in polypoidal choroidal vasculopathy during 3 years of follow-up
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Changes in fundus autofluorescence in polypoidal choroidal vasculopathy during 3 years of follow-up Mihoko Suzuki & Fumi Gomi & Miki Sawa & Chikako Ueno & Kohji Nishida
Received: 13 December 2012 / Revised: 12 March 2013 / Accepted: 19 March 2013 # Springer-Verlag Berlin Heidelberg 2013
Abstract Purpose To investigate changes in fundus autofluorescence (FAF) during 3 years of follow-up in patients with polypoidal choroidal vasculopathy (PCV). Design Retrospective study. Methods We retrospectively reviewed the charts of 48 eyes of 47 patients (35 men, 12 women; mean age, 69.9 ± 7.1 years) with treatment-naïve PCV for whom FAF and indocyanine green angiography (ICGA) images were available at baseline and at 3 years±3 months follow-up examination. The main outcome measures were the FAF changes during 3 years of follow-up, and the correlation between them and polypoidal lesions and branching vascular networks on ICGA. Results The FAF of the polypoidal lesions showed three patterns at baseline and changes during 3 years of followup: confluent hypoautofluorescence surrounded by a hyperautofluorescent ring (86.1 %→51.4 %), confluent hypoautofluorescence without a ring (8.3 %→43.0 %), and no marked changes (5.6 %→5.6 %). The FAF in 96.2 % of resolved polypoidal lesions persisted on images with abnormal FAF during the 3 years of follow-up. The granular hypoautofluorescence at the branching vascular networks at baseline became partially confluent hypoautofluorescence in 41 eyes (85.4 %). The mean area with confluent hypoautofluorescence that corresponded to the branching vascular network lesions increased significantly (P
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