• PDF / 963,029 Bytes
• 8 Pages / 595.276 x 790.866 pts Page_size
• 51 Downloads / 170 Views

DOWNLOAD

REPORT

CLINICAL STUDY

Characteristics of IDH‑mutant gliomas with non‑canonical IDH mutation L. Poetsch1 · C. Bronnimann1   · H. Loiseau2,3 · J. S. Frénel4 · A. Siegfried5 · R. Seizeur6 · G. Gauchotte7 · D. Cappellen8,9 · C. Carpentier10 · D. Figarella‑Branger11 · S. Eimer12 · D. Meyronet13,14 · F. Ducray13,14 · POLA network Received: 21 September 2020 / Accepted: 9 November 2020 © Springer Science+Business Media, LLC, part of Springer Nature 2020

Abstract Background  Approximately 10% of IDH-mutant gliomas harbour non-canonical IDH mutations (non-p.R132H IDH1 and IDH2 mutations). Objective  The aim of this study was to analyse the characteristics of non-canonical IDH-mutant gliomas. Materials and methods  We retrospectively analysed the characteristics of 166 patients with non-canonical IDH mutant gliomas and compared them to those of 155 consecutive patients with IDH1 p.R132H mutant gliomas. Results  The median age at diagnosis was 38 years in patients with non-canonical IDH mutant gliomas and 43 years in glioma patients with IDH1 p.R132H-mutant tumours. Family history of cancer was more frequent among glioma patients harbouring non-canonical IDH mutations than in patients with IDH1 p.R132H mutations (22.2% vs 5.1%; P 

Recommend Documents

Infratentorial IDH-mutant astrocytoma is a distinct subtype

151 13 5MB

Primary mismatch repair deficient IDH-mutant astrocytoma (PMMRDIA) is a distinct type with a poor prognosis

147 86 2MB

Analyses of metastasis-associated genes in IDH wild-type glioma

176 41 3MB

A nuclear transport-related gene signature combined with IDH mutation and 1p/19q codeletion better predicts the prognosi

138 35 3MB

Diffusion and perfusion MRI may predict EGFR amplification and the TERT promoter mutation status of IDH-wildtype lower-g

166 72 4MB

Correction to: Diffusion and perfusion MRI may predict EGFR amplification and the TERT promoter mutation status of IDH-w

147 103 135KB

The Comparison on the Genotype of idh-1 Between Paralichthys olivaceus and Scophthalmus maximus

140 55 12MB

Static 18 F-FET PET and DSC-PWI based on hybrid PET/MR for the prediction of gliomas defined by IDH and 1p/19q status

133 81 5MB

Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres

162 54 3MB

Infiltrative gliomas of the thalamus in children: the role of surgery in the era of H3 K27M mutant midline gliomas

155 10 3MB

Chiral discrimination in a mutated IDH enzymatic reaction in cancer: a computational perspective

147 20 1MB

1p/19q co-deletion status is associated with distinct tumor-associated macrophage infiltration in IDH mutated lower-grad

170 87 2MB