Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology,
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RESEARCH ARTICLE
Open Access
Characteristics of non-small-cell lung cancer with interstitial pneumonia: variation in cancer location, histopathology, and frequency of postoperative acute exacerbations in interstitial pneumonia Kazumasa Ogawa1,2,3,4* , Hironori Uruga1,2,5, Takeshi Fujii2,5, Sakashi Fujimori1, Tadasu Kohno1,6, Atsuko Kurosaki1,7, Kazuma Kishi1,2,8 and Shinji Abe3
Abstract Background: Non–small-cell lung cancer (NSCLC) has been reported to develop in patients with interstitial pneumonia (IP); however, clinical, radiological, and pathological features remain to be elucidated. Methods: We retrieved the records of 120 consecutive NSCLC patients associated with IP who underwent surgery at Toranomon Hospital between June 2011 and May 2017. We classified the patients into three groups according to NSCLC location using high-resolution computed tomography: group A, within a fibrotic shadow and/or at the interface of a fibrotic shadow and normal lung; group B, within emphysematous tissue and/or at the interface of emphysematous tissue and normal lung; and group C, within normal lung. In 64 patients, programmed death ligand-1 (PD-L1) status was assessed with immunohistostaining. Results: Most of the patients (89; 70%) were classified as group A. This group tended to have squamous cell carcinoma with the usual interstitial pneumonia (UIP). These cancers were located mainly in the lower lobes and seven of the eight postoperative acute exacerbations (pAE) of IP developed in this group. NSCLC in the group B were mainly squamous cell carcinomas located in the upper lobes. No patient with PD-L1 negative was classified into group B. None of the patients in group C showed UIP. and most of the cancers were adenocarcinoma. The frequency of epidermal growth factor receptor mutation-positive NSCLC was the highest in this group. Conclusions: The three groups each showed characteristic features in terms of tumor location, histopathology, PDL1 expression, and frequency of pAEof IP. Keywords: Interstitial lung disease, Non–small-cell lung cancer, Video-assisted thoracic surgery, Acute exacerbation, Cancer location, Pulmonary emphysema
* Correspondence: [email protected] 1 Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, 2-2-2, Toranomon, Minato-ku, Tokyo, Japan 2 Okinaka Memorial Institute for Medical Research, 2-2-2, Toranomon, Minato-ku, Tokyo, Japan Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not incl
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