Chemosensory dysfunction in COVID-19 out-patients
- PDF / 698,088 Bytes
- 8 Pages / 595.276 x 790.866 pts Page_size
- 45 Downloads / 166 Views
RHINOLOGY
Chemosensory dysfunction in COVID‑19 out‑patients María Jesús Rojas‑Lechuga1,2,3 · Adriana Izquierdo‑Domínguez4,5,6 · Carlos Chiesa‑Estomba7 · Christian Calvo‑Henríquez8 · Ithzel Maria Villarreal9 · Genoveva Cuesta‑Chasco10 · Manuel Bernal‑Sprekelsen1,2,3 · Joaquim Mullol1,2,3,11 · Isam Alobid1,2,3,5,11 Received: 3 June 2020 / Accepted: 31 July 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background Since the outbreak in China due to coronavirus disease 2019 (COVID-19) various studies have been published describing olfactory and gustatory dysfunction (OGD). Objective The aim was to investigate the frequency and severity of OGD in SARS-CoV-2 (+) out-patients compared to controls with common cold/flu like symptoms and two negative RT-PCR. Methods A multicenter cross-sectional study on SARS-CoV-2-positive out-patients (n = 197) and controls (n = 107) from five Spanish Hospitals. Severity of OGD was categorized by visual analogue scale (VAS). Frequency and severity of the chemosensory impairment were analyzed. Results The frequencies of smell (70.1%) and taste loss (65%) were significantly higher among COVID-19 subjects than in the controls (20.6% and 19.6%, respectively). Simultaneous OGD was more frequent in the COVID-19 group (61.9% vs 10.3%) and they scored higher in VAS for severity of OGD than controls. In the COVID-19 group, OGD was predominant in young subjects 46.5 ± 14.5 and females (63.5%). Subjects with severe loss of smell were younger (42.7 years old vs 45.5 years old), and recovered later (median = 7, IQR = 5.5 vs median = 4, IQR = 3) than those with mild loss of smell. Subjects with severe loss of taste, recovered later in days (median = 7, IQR = 6 vs median = 2, IQR = 2), compared to those with mild loss. Conclusion OGD is a prevalent symptom in COVID-19 subjects with significant differences compared to controls. It was predominant in young and females subjects. Stratified analysis by the severity of OGD showed that more than 60% of COVID19 subjects presented a severe OGD who took a longer time to recover compared to those with mild symptoms. Keywords Hyposmia · Anosmia · Ageusia · Taste loss · SARS-CoV-2 · COVID-19 · Out-patients
Introduction Coronavirus disease 2019 (COVID-19) outbreak was declared a Public Health Emergency of International Concern on 30 January 2020 by the World Health Organization (OMS) [1]. To date, more than 5 million people (5,593,631 María Jesús Rojas-Lechuga and Adriana Izquierdo-Domínguez have equally contributed as main authors. Joaquim Mullol and Isam Alobid have equally contributed as senior authors. * Joaquim Mullol [email protected] * Isam Alobid [email protected]
as of May 28th, 2020) have been diagnosed, and more than 350,000 deaths have been reported [1]. Although many people develop respiratory symptoms [2], a considerable number of cases are asymptomatic or pre-symptomatic with a larger incubation period (potentially lasting longer than 14 days), resulting in a large number of carriers [3]. This fact, associated
Data Loading...
