Chemotherapy-induced grey matter abnormalities in cancer survivors: a voxel-wise neuroimaging meta-analysis
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Chemotherapy-induced grey matter abnormalities in cancer survivors: a voxel-wise neuroimaging meta-analysis Running Niu 1 & Mingying Du 1 & Jing Ren 1 & Haomiao Qing 1 & Xiaodong Wang 1 & Guohui Xu 1 & Du Lei 2 & Peng Zhou 1 Received: 12 July 2019 / Revised: 21 July 2020 / Accepted: 15 September 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract Background Findings regarding chemotherapy-induced grey matter abnormalities are heterogeneous, and no meta-analysis has quantitatively assessed brain structural alterations in cancer survivors treated with chemotherapy. Purpose To investigate the grey matter abnormalities in non-CNS (central nervous system) cancer survivors treated with chemotherapy using Anisotropic Effect Size Signed Differential Mapping (AES-SDM) software. Method We identified studies published up to Sep 2018 that compared grey matter in non-CNS cancer survivors treated with chemotherapy (CT+, 10 data sets including 433 individuals) and cancer survivors not treated with chemotherapy (CT-, 7 data sets including 210 individuals) or healthy controls (HC, 3 data sets including 407 individuals) using whole-brain VBM. We used statistical maps from the studies included where available and reported peak coordinates otherwise. Results Compared with both CT- and HC, the CT + groups exhibited a reduced grey matter volume (GMV), mainly in the prefrontal and anterior cingulate cortex (ACC) and right fusiform gyrus (FG). A smaller GMV in the FG and prefrontal cortex were found in the CT + compared with the CT-groups and in the CT + groups with impaired cognition. GMV in two areas was positively associated with the time since chemotherapy. Conclusions The present results suggest that non-CNS cancer survivors treated with chemotherapy exhibit grey matter abnormalities in the brain, especially in the prefrontal and ACC cortex. Grey matter volume changes after chemotherapy may contribute to cognitive impairments in cancer survivors that can be observed after chemotherapy. Keywords Magnetic resonance imaging . Voxel based morphometry . Cognitive impairments . Cancer survivors . Chemotherapy . Meta-analysis
Introduction Running Niu and Mingying Du contributed equally to this work. A meta-analysis of grey matter in chemo-cancer survivors. Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11682-020-00402-7) contains supplementary material, which is available to authorized users. * Du Lei [email protected] * Peng Zhou [email protected] 1
Department of Radiology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China
2
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati, 260 Stetson St., Suite 3326, Cincinnati, OH, USA
With the increasing incidence of cancer and improvement of treatment over recent decades, an increasing number of individuals with cancer are experiencing long-term survival following ini
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