Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy
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COMPUTED TOMOGRAPHY
Chest CT for detecting COVID-19: a systematic review and meta-analysis of diagnostic accuracy Buyun Xu 1 & Yangbo Xing 1 & Jiahao Peng 2 & Zhaohai Zheng 3 & Weiliang Tang 1 & Yong Sun 1 & Chao Xu 1 & Fang Peng 1 Received: 14 April 2020 / Accepted: 4 May 2020 # European Society of Radiology 2020
Abstract Objective The purpose of this article was to perform a systematic review and meta-analysis regarding the diagnostic test accuracy of chest CT for detecting coronavirus disease 2019 (COVID-19). Methods PubMed, Embase, Web of Science, and CNKI were searched up to March 12, 2020. We included studies providing information regarding diagnostic test accuracy of chest CT for COVID-19 detection. The methodological quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Sensitivity and specificity were pooled. Results Sixteen studies (n = 3186 patients) were included. The risks of bias in all studies were moderate in general. Pooled sensitivity was 92% (95% CI = 86–96%), and two studies reported specificity (25% [95% CI = 22–30%] and 33% [95% CI = 23– 44%], respectively). There was substantial heterogeneity according to Cochran’s Q test (p < 0.01) and Higgins I2 heterogeneity index (96% for sensitivity). After dividing the studies into two groups based on the study site, we found that the sensitivity of chest CT was great in Wuhan (the most affected city by the epidemic) and the sensitivity values were very close to each other (97%, 96%, and 99%, respectively). In the regions other than Wuhan, the sensitivity varied from 61 to 98%. Conclusion Chest CT offers the great sensitivity for detecting COVID-19, especially in a region with severe epidemic situation. However, the specificity is low. In the context of emergency disease control, chest CT provides a fast, convenient, and effective method to early recognize suspicious cases and might contribute to confine epidemic. Key Points • Chest CT has a high sensitivity for detecting COVID-19, especially in a region with severe epidemic, which is helpful to early recognize suspicious cases and might contribute to confine epidemic. Keywords X-ray computed tomography . Coronaviruses . Pneumonias
Abbreviations COVID-19 GGO RT-PCR SARS-CoV-2
Introduction Coronavirus disease 19 Ground-glass opacity Reverse transcription polymerase chain reaction Severe acute respiratory syndrome coronavirus 2
In December 2019, an outbreak of pneumonia associated with a novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in Wuhan, Hubei Province, China [1]. Thereafter, the WHO named the disease as coronavirus disease 2019 (COVID-19). With virus spreading globally, the WHO characterizes COVID-19 as a pandemic.
Buyun Xu and Yangbo Xing contributed equally to this work. * Fang Peng [email protected] 1
Department of Cardiology, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), No. 568, Zhongxing North Road, Shaoxing 312000, Zhejiang Province, People’s Republic of Chin
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